Tachibana Tetsuya, Nakai Yasua, Makino Ryosuke, Khan Md Sakirul Islam, Cline Mark A
Department of Agrobiological Science, Faculty of Agriculture, Ehime University, Matsuyama, 790-8566, Japan.
Department of Agrobiological Science, Faculty of Agriculture, Ehime University, Matsuyama, 790-8566, Japan.
Prostaglandins Other Lipid Mediat. 2018 Jul;137:46-51. doi: 10.1016/j.prostaglandins.2018.06.002. Epub 2018 Jun 21.
Prostaglandin D2 (PGD2) is associated with a diverse array of functions in mammals including regulation of appetite, body temperature, sleep, and immune responses. Although much is known about the effects of PGD2 in mammals, there is a lack of information about its effects in birds. Therefore, the purpose of the present study was to determine if intracerebroventricular (ICV) and intraperitoneal (IP) injections of PGD2 affect feeding, voluntary movement, crop-emptying rate, corticosterone release, and cloacal temperature in chicks (Gallus gallus). ICV injection of PGD2 was associated with a reduction in food intake, a reduction in voluntary movement, an increase in the time spent sitting, a decline in crop emptying rate, and also short-term hypothermia. Central injection of PGD2 also decreased the plasma glucose concentration in chicks while it tended to increase the plasma corticosterone concentration. On the other hand, except for crop emptying, such physiological changes are not observed after IP injection of PGD2. In sum, the present study suggests that PGD2 induces anorexia, change in behavior, decline in crop empting rate, hypoglycemia and hypothermia, but most of these effects are exerted via central nervous system in chicks.
前列腺素D2（PGD2）在哺乳动物中具有多种功能，包括调节食欲、体温、睡眠和免疫反应。尽管人们对PGD2在哺乳动物中的作用了解很多，但关于其在鸟类中的作用却缺乏相关信息。因此，本研究的目的是确定脑室内（ICV）和腹腔内（IP）注射PGD2是否会影响雏鸡（家鸡）的进食、自主运动、嗉囊排空率、皮质酮释放和泄殖腔温度。脑室内注射PGD2与食物摄入量减少、自主运动减少、静息时间增加、嗉囊排空率下降以及短期体温过低有关。脑室内注射PGD2还会降低雏鸡的血浆葡萄糖浓度，同时倾向于增加血浆皮质酮浓度。另一方面，除了嗉囊排空外，腹腔注射PGD2后未观察到此类生理变化。总之，本研究表明，PGD2会诱发厌食、行为改变、嗉囊排空率下降、低血糖和体温过低，但这些影响大多是通过雏鸡的中枢神经系统发挥作用的。
