Silverberg Jonathan I, Patel Nisha, Warshaw Erin M, DeKoven Joel G, Belsito Donald V, Atwater Amber Reck, Houle Marie-Claude, Taylor James S, Reeder Margo J, Zug Kathryn A, Sasseville Denis, DeLeo Vincent A, Pratt Melanie D, Fowler Joseph F, Maibach Howard I
Department of Dermatology, George Washington University School of Medicine, Washington DC.
Department of Dermatology, George Washington University School of Medicine, Washington DC.
J Am Acad Dermatol. 2022 Nov;87(5):1049-1059. doi: 10.1016/j.jaad.2022.07.035. Epub 2022 Aug 5.
Dermatitis localized to hands (HD), feet (FD), or both hands and feet (HFD) has multiple etiologies, including atopic dermatitis, irritant contact dermatitis, and allergic contact dermatitis. Unfortunately, little is known about clinical differences between patients with HD, FD, and HFD.
To characterize differences in demographics, etiology, and patch testing results among patients presenting with HD, FD, or HFD referred for patch testing.
A retrospective analysis of patients patch tested by the North American Contact Dermatitis Group between 2001 and 2018.
Of 43,677 patients who were patch tested, 22.8% had HD, 2.9% had FD, and 3.7% had HFD. Allergic and currently relevant patch test reactions to ≥1 North American Contact Dermatitis Group screening allergen occurred in similar proportions in all 3 study groups. However, HD (18.0%) had higher proportions of occupationally relevant reactions than HFD (8.9%) or FD (4.0%). Nickel and fragrance mix I were in the top 5 currently relevant allergens for HD, FD, and HFD. Other top allergens, as well as allergen sources, differed between HD, FD, and HFD.
No data on HD or FD morphology or distribution.
HD, FD, and HFD have several differences with respect to patient characteristics, etiologies, and clinically relevant allergens.
局限于手部（HD）、足部（FD）或手足均受累（HFD）的皮炎有多种病因，包括特应性皮炎、刺激性接触性皮炎和过敏性接触性皮炎。遗憾的是，关于HD、FD和HFD患者之间的临床差异知之甚少。
描述因斑贴试验转诊的HD、FD或HFD患者在人口统计学、病因和斑贴试验结果方面的差异。
对2001年至2018年期间北美接触性皮炎小组进行斑贴试验的患者进行回顾性分析。
在43677例接受斑贴试验的患者中，22.8%患有HD，2.9%患有FD，3.7%患有HFD。在所有3个研究组中，对≥1种北美接触性皮炎小组筛查变应原发生的过敏和当前相关斑贴试验反应比例相似。然而，HD（18.0%）中职业相关反应的比例高于HFD（8.9%）或FD（4.0%）。镍和香料混合物I在HD、FD和HFD的前5种当前相关变应原中。HD、FD和HFD之间的其他主要变应原以及变应原来源有所不同。
无关于HD或FD形态或分布的数据。
HD、FD和HFD在患者特征、病因和临床相关变应原方面存在若干差异。
