Cegolon Luca, Badalini Alessandro, Larese Filon Francesca
Department of Medical, Surgical & Health Sciences, University of Trieste, 34128 Trieste, Italy.
Public Health Department, University Health Agency Giuliano-Isontina (ASUGI), 34128 Trieste, Italy.
Life (Basel). 2025 Apr 25;15(5):698. doi: 10.3390/life15050698.
. Skin contact with items containing p-tert-butylphenol-formaldehyde resin (PTBP-FR) may induce sensitization and allergic contact dermatitis (ACD). . This multi-centric cross-sectional study investigated the prevalence of sensitization to PTBP-FR in 30,629 consecutive outpatients patch-tested during 1997-2021 in four research centers from Northern Italy: Padua; Pordenone; Trieste; and Trento/Bolzano/Rovigo. Patch tests were applied on the upper back of patients with suspected ACD. All patches were removed after 48 h and read at 72 or 96 h. . The overall prevalence of PTBP-FR sensitization was 1.11% (=341/30,629) of cases, with lower prevalence occurring in the Province of Trento/Bolzano/Rovigo (0.36%). The body area most frequently affected were the hands (36.32%), followed by face (19.52%) and legs (8.09%). During 1997-2004, the prevalence of PTBP-FR positivity was significantly lower in Trento/Bolzano/Rovigo (aOR = 0.19; 95%CI: 0.11; 0.35), whereas it was higher among restaurant workers (aOR = 2.44; 95%CI: 1.44; 4.13). During the entire study period (1997-2021), excluding Trento/Bolzano/Rovigo, PTBP-FR positivity significantly decreased in the period 2011-2021 (aOR = 052; 95%CI: 0.39; 0.69) compared to 1997-2010 in males (OR = 0.69; 95%CI: 0.52; 0.91). . Females were likely to react to PTBP-FR at patch tests. Prevalence of PTBP-FR sensitization significantly decreased over time, possibly reflecting reduced occupational and non-occupational exposure due to replacement of the resin with other adhesive products (acrylates or epoxy agents).
皮肤接触含有对叔丁基苯酚甲醛树脂（PTBP - FR）的物品可能会引起致敏和过敏性接触性皮炎（ACD）。 这项多中心横断面研究调查了1997年至2021年期间在意大利北部四个研究中心（帕多瓦、波代诺内、的里雅斯特以及特伦托/博尔扎诺/罗维戈）连续接受斑贴试验的30629名门诊患者中对PTBP - FR的致敏率。斑贴试验应用于疑似ACD的患者背部上方。所有贴片在48小时后去除，并在72或96小时读取结果。 PTBP - FR致敏的总体患病率为病例的1.11%（= 341 / 30629），在特伦托/博尔扎诺/罗维戈省患病率较低（0.36%）。最常受影响的身体部位是手部（36.32%），其次是面部（19.52%）和腿部（8.09%）。在1997 - 2004年期间，特伦托/博尔扎诺/罗维戈的PTBP - FR阳性率显著较低（aOR = 0.19；95%CI：0.11；0.35），而餐厅工作人员中的阳性率较高（aOR = 2.44；95%CI：1.44；4.13）。在整个研究期间（1997 - 2021年），不包括特伦托/博尔扎诺/罗维戈，与1997 - 2010年相比，2011 - 2021年期间男性的PTBP - FR阳性率显著下降（aOR = 0.52；95%CI：0.39；0.69）（OR = 0.69；95%CI：0.52；0.91）。 女性在斑贴试验中对PTBP - FR更易产生反应。PTBP - FR致敏率随时间显著下降，这可能反映出由于用其他粘合剂产品（丙烯酸酯或环氧剂）替代该树脂，职业和非职业接触减少。
