活性硫和硒物种在骨稳态调节中的作用。
Reactive sulfur and selenium species in the regulation of bone homeostasis.
机构信息
Department of Chemistry and Biochemistry, Materials Science Institute, Knight Campus for Accelerating Scientific Impact, Institute of Molecular Biology, University of Oregon, Eugene, OR, 97403, United States.
Department of Chemistry and Biochemistry, Materials Science Institute, Knight Campus for Accelerating Scientific Impact, Institute of Molecular Biology, University of Oregon, Eugene, OR, 97403, United States.
出版信息
Free Radic Biol Med. 2022 Sep;190:148-157. doi: 10.1016/j.freeradbiomed.2022.08.002. Epub 2022 Aug 5.
Reactive oxygen species (ROS) are important modulators of physiological signaling and play important roles in bone tissue regulation. Both reactive sulfur species (RSS) and reactive selenium species (RSeS) are involved in ROS signaling, and recent work suggests RSS and RSeS involvement in the regulation of bone homeostasis. For example, RSS can promote osteogenic differentiation and decrease osteoclast activity and differentiation, and the antioxidant activity of RSeS play crucial roles in balancing bone remodeling. Here, we outline current research progress on the application of RSS and RSeS in bone disease and regeneration. Focusing on these investigations, we highlight different methods, tools, and sources of RSS and RSeS, and we also highlight future opportunities for delivery of RSS and RSeS in biological environments relating to bone.
活性氧（ROS）是生理信号的重要调节剂，在骨组织调节中发挥着重要作用。活性硫（RSS）和活性硒（RSeS）都参与了 ROS 信号转导，最近的研究表明 RSS 和 RSeS 参与了骨稳态的调节。例如，RSS 可以促进成骨分化，减少破骨细胞的活性和分化，而 RSeS 的抗氧化活性在平衡骨重塑中起着至关重要的作用。在这里，我们概述了 RSS 和 RSeS 在骨疾病和再生中的应用的最新研究进展。我们重点介绍了这些研究中的不同方法、工具和 RSS 和 RSeS 的来源，并强调了在与骨相关的生物环境中输送 RSS 和 RSeS 的未来机遇。
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