Key Laboratory of Chemical Biology and Molecular Engineering of Ministry of Education, Institute of Molecular Science, Shanxi University, Taiyuan, 030006, P. R. China.
Research Institute of Applied Chemistry, Shanxi University, Taiyuan, 030006, P. R. China.
Chem Asian J. 2022 Dec 1;17(23):e202200907. doi: 10.1002/asia.202200907. Epub 2022 Oct 28.
Intracellular redox homeostasis exerts a tremendous influence on pathophysiological fields. In order to maintain the homeostasis of intracellular redox state, reactive oxygen species (ROS) and reactive sulfur species (RSS) react and transform with each other, and their levels also directly reflect the degree of oxidative stress and disease. To understand the correlation and pathophysiological effects of these two signaling molecules in oxidative stress, unique fluorescence imaging tools are required. Fluorescent probes have become an indispensable detection tool in modern scientific research and disease diagnosis. Currently, there are many fluorescent probes for detecting ROS or RSS. However, the cellular environment is extremely complex. Dual detection fluorescent probes that can monitor more than one species in a biological environment cause our attention. This review describes dual detection fluorescent probes that can detect ROS and RSS simultaneously or sequentially. This will provide strong support for the study of redox homeostasis.
细胞内氧化还原稳态对病理生理学领域有巨大影响。为了维持细胞内氧化还原状态的稳态，活性氧（ROS）和活性硫（RSS）相互反应和转化，它们的水平也直接反映了氧化应激和疾病的程度。为了了解这两种信号分子在氧化应激中的相关性和病理生理学效应，需要独特的荧光成像工具。荧光探针已成为现代科学研究和疾病诊断中不可或缺的检测工具。目前，有许多用于检测 ROS 或 RSS 的荧光探针。然而，细胞环境非常复杂。能够在生物环境中同时或顺序监测多种物质的双检测荧光探针引起了我们的关注。本文综述了能够同时或顺序检测 ROS 和 RSS 的双检测荧光探针。这将为氧化还原稳态的研究提供有力支持。
