水蕹菜树脂糖苷提取物体外延缓高脂食物的脂肪消化率。
Resin glycoside extracts from Ipomoea aquatica retard lipid digestibility of high-fat food in vitro.
机构信息
Department of Food Science & Technology, National University of Singapore, 2 Science Drive 2, Singapore 117542, Singapore.
Department of Food Science & Technology, National University of Singapore, 2 Science Drive 2, Singapore 117542, Singapore; National University of Singapore (Suzhou) Research Institute, 377 Lin Quan Street, Suzhou Industrial Park, Suzhou, Jiangsu 215123, PR China.
出版信息
Food Res Int. 2022 Sep;159:111552. doi: 10.1016/j.foodres.2022.111552. Epub 2022 Jun 28.
Due to the considerable increase in the prevalence of obesity, there is an increased interest in developing safe and effective anti-obesity treatments from fruits and vegetables. In this study, Ipomoea aquatica, commonly known as Kang Kong in Southeast Asia was first reported to contain potent pancreatic lipase (PL) inhibitors due to resin glycosides (RG). Ipomoea aquatica extract demonstrated a dose-dependent inhibitory activity against PL with an Orlistat equivalent (OE) value of 6.86 ± 0.51 × 10. In vitro lipolysis study showed that consuming RG in tandem with high-fat food (butter & salad dressing) was effective in delaying enzymatic fat digestion by inhibiting PL. Pre-incubation of PL with RG extract before substrate addition also significantly enhanced their inhibitory activity. However, RG was unstable when subjected to high heat treatments (90 °C). Overall, these results provided useful knowledge of RG as PL inhibitors for body weight management.
由于肥胖症的患病率显著增加，人们越来越关注从水果和蔬菜中开发安全有效的抗肥胖症治疗方法。在这项研究中，首次报道了东南亚地区常见的蕹菜（Ipomoea aquatica）含有有效的胰腺脂肪酶（PL）抑制剂，这归因于树脂糖苷（RG）。Ipomoea aquatica 提取物对 PL 具有剂量依赖性抑制活性，其奥利司他当量（OE）值为 6.86±0.51×10。体外脂肪分解研究表明，与高脂肪食物（黄油和沙拉酱）一起摄入 RG 可通过抑制 PL 有效延迟酶促脂肪消化。在添加底物之前，将 PL 与 RG 提取物预孵育也显著增强了它们的抑制活性。然而，RG 在经受高温处理（90°C）时不稳定。总的来说，这些结果为 RG 作为用于体重管理的 PL 抑制剂提供了有用的知识。
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