内质网中蛋白质的分拣和输出。
Sorting and Export of Proteins at the Endoplasmic Reticulum.
机构信息
Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, Barcelona 08003, Spain
Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, Barcelona 08003, Spain.
出版信息
Cold Spring Harb Perspect Biol. 2023 May 2;15(5):a041258. doi: 10.1101/cshperspect.a041258.
Abstract
Secretory proteins are transported from the endoplasmic reticulum (ER) to the Golgi complex in carriers that are formed by the concerted activities of cytoplasmic proteins in the coat protein complex II (COPII). COPII was first described in and its basic functions are largely conserved throughout eukaryotes. The discovery of the TANGO1 (transport and Golgi organization 1) family of proteins is revealing insights into how cells can adapt COPII proteins to reorganize the ER exit site for the export of the most abundant and bulky molecules, collagens.
摘要
分泌蛋白通过由细胞质蛋白在衣壳蛋白复合物 II (COPII) 中的协同作用形成的载体从内质网 (ER) 运输到高尔基体复合物。COPII 最初在 中被描述，其基本功能在真核生物中基本保持保守。TANGO1（运输和高尔基体组织 1）蛋白家族的发现揭示了细胞如何能够使 COPII 蛋白重新组织 ER 出口以输出最丰富和最大的分子胶原蛋白。
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