Dermatology & Andrology Department, Faculty of Medicine, Suez Canal University, Ismailia, Egypt.
Diagnostic Radiology Department, Faculty of Medicine, Suez Canal University, Ismailia, Egypt.
J Dermatolog Treat. 2022 Dec;33(8):3154-3159. doi: 10.1080/09546634.2022.2112137. Epub 2022 Aug 18.
BACKGROUND/OBJECTIVES: Psoriasis, newly considered as a systemic inflammatory condition, has a high prevalence of cardiovascular diseases (CVDs), including atherosclerosis and myocardial infarction. Measurement of carotid artery intima-media thickness (C-IMT) represents a noninvasive diagnostic tool for predicting cardiovascular disorders. We aimed to determine if psoriatic patients have an increased risk for the development of cardiovascular disorders by assessment of the presence of subclinical atherosclerosis in psoriasis patients.
Forty adult psoriatic patients and 40 matched healthy controls were selected in this study. All participants were subjected to full history, examination, assessment of the severity of psoriasis using psoriasis area and severity index (PASI) score, measuring serum lipid profile (cholesterol, low density lipoprotein (LDL) and triglycerides) and C-IMT.
Psoriatic patients showed significantly higher serum lipid profile findings and C-IMT. There was a positive statistically significant correlation between C-IMT and each of age of the patients ( = 0.760, <.001) and severity of psoriasis (PASI score).
There is increased susceptibility to CVDs in psoriatic patients represented by increased incidence of subclinical atherosclerosis and dyslipidemia in our patients.
背景/目的：银屑病，新被认为是一种系统性炎症性疾病，其心血管疾病（CVDs）的患病率很高，包括动脉粥样硬化和心肌梗死。颈动脉内膜中层厚度（C-IMT）的测量是预测心血管疾病的一种非侵入性诊断工具。我们旨在通过评估银屑病患者亚临床动脉粥样硬化的存在，确定银屑病患者是否存在发生心血管疾病的风险增加。
本研究选择了 40 名成年银屑病患者和 40 名匹配的健康对照者。所有参与者均接受详细的病史、检查、银屑病面积和严重程度指数（PASI）评分评估、血脂谱（胆固醇、低密度脂蛋白（LDL）和甘油三酯）和 C-IMT 测量。
银屑病患者的血清脂质谱和 C-IMT 结果明显更高。C-IMT 与患者年龄（ = 0.760，<.001）和银屑病严重程度（PASI 评分）之间存在正相关。
我们的患者中存在亚临床动脉粥样硬化和血脂异常，表明银屑病患者对 CVDs 的易感性增加。
