恒河猴肾成纤维细胞（cmKF）来源的诱导多能干细胞（cmKF-iPS-C5）的生成与鉴定。
Generation and characterization of cynomolgus monkey kidney fibroblasts (cmKF)-derived induced pluripotent stem cells (cmKF-iPS-C5).
机构信息
National Primate Research Center (NPRC), Korea Research Institute of Bioscience and Biotechnology (KRIBB), Cheongju, Republic of Korea; Department of Nanoscience and Nanotechnology, Graduate School, Kyungpook National University, Daegu, Republic of Korea.
National Primate Research Center (NPRC), Korea Research Institute of Bioscience and Biotechnology (KRIBB), Cheongju, Republic of Korea; Department of Internal Medicine, School of Medicine, Kangwon National University, Chuncheon, Republic of Korea.
出版信息
Stem Cell Res. 2022 Oct;64:102887. doi: 10.1016/j.scr.2022.102887. Epub 2022 Aug 3.
Cynomolgus monkeys, a non-human primate species, are genetically and physiologically similar to humans; hence, they have been employed as an ideal developmental and biomedical model. Non-human primate animals and their induced pluripotent stem cell (iPSC) derivatives have been used as a research tool to investigate autologous regenerative medicine. Here, we reprogrammed cynomolgus monkey kidney fibroblasts (cmKFs) as a control for animal iPSCs and to study autologous transplant. The resulting cmKF-iPSCs, which displayed canonical characteristics of PSCs, could be used as a unique model for autologous cell-based therapy.
食蟹猴，一种非人类灵长类动物，在基因和生理上与人类相似；因此，它们被用作理想的发育和生物医学模型。非人类灵长类动物及其诱导多能干细胞（iPSC）衍生物已被用作研究自体再生医学的研究工具。在这里，我们将食蟹猴肾成纤维细胞（cmKFs）重编程为动物 iPSC 的对照，以研究自体移植。所得的 cmKF-iPSCs 显示出 PSCs 的典型特征，可作为自体细胞治疗的独特模型。
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