Zhen Xing, Park Sang-Je, Choe Se-Hee, Lee Dong-Seok, Lee Jong-Hee
National Primate Research Center (NPRC), Korea Research Institute of Bioscience and Biotechnology (KRIBB), Cheongju, Republic of Korea; Department of Nanoscience and Nanotechnology, Graduate School, Kyungpook National University, Daegu, Republic of Korea.
National Primate Research Center (NPRC), Korea Research Institute of Bioscience and Biotechnology (KRIBB), Cheongju, Republic of Korea.
Stem Cell Res. 2022 Dec;65:102977. doi: 10.1016/j.scr.2022.102977. Epub 2022 Nov 15.
Cynomolgus monkeys, due to their close anatomical, genetic and physiological similarity to humans, have been employed as a popular laboratory non-human primate model over rodents. Primate animal induced pluripotent stem cell (iPSC) have been used to aid on the investigation of autologous regenerative therapies. Here, we reprogrammed cynomolgus monkey ear skin fibroblasts (cmESFs) into iPSCs as a starting material for autologous based study. The resulting cmESF-iPSCs with canonical features of PSCs will advance the development of autologous transplantation.
食蟹猴由于在解剖学、遗传学和生理学上与人类高度相似，已成为一种比啮齿动物更常用的实验室非人类灵长类动物模型。灵长类动物诱导多能干细胞（iPSC）已被用于辅助自体再生疗法的研究。在此，我们将食蟹猴耳部皮肤成纤维细胞（cmESFs）重编程为iPSC，作为自体研究的起始材料。所得具有多能干细胞典型特征的cmESF-iPSC将推动自体移植的发展。
