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MVE-2对荷瘤小鼠和正常小鼠天然细胞活性的增强作用。

Augmentation of natural cell activity in tumor-bearing and normal mice by MVE-2.

作者信息

Budzynski W, Chirigos M, Gruys E

出版信息

Cancer Immunol Immunother. 1987;24(3):253-8. doi: 10.1007/BF00205639.

DOI:10.1007/BF00205639

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11038214/

Abstract

Mice bearing advanced Lewis lung carcinoma were found to have significantly decreased natural killer (NK) cell activity in spleen and blood. The same pattern of lowered spontaneous NK cell activity was observed in nude mice with advanced human colon carcinoma LS 174 and in C3H mammary tumor virus-positive mice that spontaneously developed mammary adenocarcinomas. Maleic anhydride divinyl ether (MVE-2) usually augments NK cell activity in normal mice. We found that the lower level of spontaneous NK cell activity in tumor-bearing mice could be boosted by a single injection of MVE-2; however, this response was much weaker than that observed in age-matched normal mice. Multiple treatments with MVE-2 which are known to induce hyporesponsiveness to further augmentation of NK cell activity in spleen and blood of normal mice, also produced NK cell hyporesponsiveness in the spleen, bone marrow, and blood of tumor-bearing mice.

摘要

研究发现，患有晚期Lewis肺癌的小鼠脾脏和血液中的自然杀伤（NK）细胞活性显著降低。在患有晚期人类结肠癌LS 174的裸鼠以及自发发生乳腺腺癌的C3H乳腺肿瘤病毒阳性小鼠中，也观察到了相同的自发性NK细胞活性降低模式。马来酸酐二乙烯基醚（MVE-2）通常会增强正常小鼠的NK细胞活性。我们发现，单次注射MVE-2可以提高荷瘤小鼠自发性NK细胞活性的较低水平；然而，这种反应比在年龄匹配的正常小鼠中观察到的要弱得多。已知多次使用MVE-2会导致正常小鼠脾脏和血液中NK细胞活性对进一步增强产生低反应性，在荷瘤小鼠的脾脏、骨髓和血液中也产生了NK细胞低反应性。