Janiak M, Budzynski W, Gnatowski B, Radzikowski C, Szmigielski S, Jeljaszewicz J, Pulverer G
Immunobiology. 1984 Oct;167(4):328-37. doi: 10.1016/S0171-2985(84)80004-2.
Propionibacterium granulosum KP-45, glucan and pyran copolymer stimulated the elimination of 75Selenomethionine-labelled 3LL tumor cells from murine lungs, as measured 4 hr after intravenous injection of these cells into 16- to 25-week-old B6DF1 mice. This effect was most pronounced 4 to 6 days following intravenous administration of the above biological response modifiers and disappeared 6 to 8 days later. Intraperitoneal injection of all three agents produced only insignificant stimulation results. Spontaneous clearance of 3LL cells from lungs of 8-week-old B6DF1 mice was significantly more effective than in animals over 16 weeks old. Cyclophosphamide suppressed the elimination of tumor cells from lungs in both young and older mice and neutralized the stimulatory effect of P. granulosum KP-45 and glucan. The results suggest that the effector cells responsible for the clearance of radiolabelled 3LL cells from lungs of B6DF1 mice are at least similar to natural killer (NK) lymphocytes.
颗粒丙酸杆菌KP - 45、葡聚糖和吡喃共聚物能促进从鼠肺中清除75硒代蛋氨酸标记的3LL肿瘤细胞，这是在将这些细胞静脉注射到16至25周龄的B6DF1小鼠体内4小时后测得的。在静脉注射上述生物反应调节剂后的4至6天，这种效果最为明显，并在6至8天后消失。腹腔注射所有这三种制剂仅产生不显著的刺激结果。8周龄B6DF1小鼠肺中3LL细胞的自发清除比16周龄以上的动物更有效。环磷酰胺抑制了年轻和年老小鼠肺中肿瘤细胞的清除，并中和了颗粒丙酸杆菌KP - 45和葡聚糖的刺激作用。结果表明，负责从B6DF1小鼠肺中清除放射性标记的3LL细胞的效应细胞至少与自然杀伤（NK）淋巴细胞相似。
