Army Institute of Hepatobiliary Surgery, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, China.
Department of Neurosurgery, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, China.
Int J Hyperthermia. 2022;39(1):1052-1063. doi: 10.1080/02656736.2022.2059581.
The purpose of this article is to discuss the use, comparative efficacy, and research progress of radiofrequency ablation (RFA), alone or in combination with other therapies, for the treatment of hepatocellular carcinoma (HCC).
To search and summarize the basic and clinical studies of RFA in recent years.
RFA is one of the radical treatment methods listed in the guidelines for the diagnosis and treatment of HCC. It has the characteristics of being minimally invasive and safe and can obtain good local tumor control, and it can improve the local immune ability, improve the tumor microenvironment and enhance the efficacy of chemotherapy drugs. It is commonly used for HCC treatment before liver transplantation and combined ALPPS and hepatectomy for HCC. In addition, the technology of RFA is constantly developing. The birth of noninvasive, no-touch RFA technology and equipment and the precise RFA concept have improved the therapeutic effect of RFA.
RFA has good local tumor control ability, is minimally invasive, is safe and has other beneficial characteristics. It plays an increasingly important role in the comprehensive treatment strategy of HCC. Whether RFA alone or combined with other technologies expands the surgical indications of patients with HCC and provides more benefits for HCC patients needs to be determined.
本文旨在讨论射频消融（RFA）单独或联合其他疗法治疗肝细胞癌（HCC）的应用、比较疗效和研究进展。
检索并总结近年来 RFA 的基础和临床研究。
RFA 是 HCC 诊断和治疗指南中列出的根治性治疗方法之一，具有微创、安全的特点，能获得良好的局部肿瘤控制，同时能提高局部免疫能力，改善肿瘤微环境，增强化疗药物的疗效。RFA 常用于肝移植前 HCC 的治疗，联合 ALPPS 和肝切除术治疗 HCC。此外，RFA 技术不断发展，无创、无接触 RFA 技术和设备的诞生，以及精确 RFA 理念的提出，提高了 RFA 的治疗效果。
RFA 具有良好的局部肿瘤控制能力，微创、安全，具有其他有益的特点，在 HCC 的综合治疗策略中发挥着越来越重要的作用。RFA 单独或联合其他技术是否能扩大 HCC 患者的手术适应证，为 HCC 患者带来更多获益，尚需进一步确定。
