Department of Respiratory Medicine, Nagasaki University Graduate School of Biomedical Sciences, Japan.
Department of Pathology, Nagasaki University Graduate School of Biomedical Sciences, Japan.
Intern Med. 2023 Mar 15;62(6):877-880. doi: 10.2169/internalmedicine.0139-22. Epub 2022 Aug 10.
A 36-year-old Japanese man presented with cavities and nodular shadows in the lower lobes of his lungs and osteolytic lesions in the thoracic spine. He was diagnosed with multisystem Langerhans cell histiocytosis (LCH). Three years earlier, he had been noted to have small cavities and granular lesions noted in the upper lobes of his lungs, which later improved with smoking cessation. It was likely that his single-system pulmonary LCH (PLCH) progressed to multisystem LCH despite smoking cessation. Relapse or progression may occur in cases where PLCH lesions improve after smoking cessation. Thus, close follow-up is vital.
一位 36 岁的日本男性因肺部下叶的空洞和结节状阴影以及胸腰椎的溶骨性病变就诊。他被诊断为多系统朗格汉斯细胞组织细胞增生症（LCH）。三年前，他曾被发现肺部上叶有小空洞和颗粒状病变，后来戒烟后有所改善。尽管他已经戒烟，但他的单系统肺朗格汉斯细胞组织细胞增生症（PLCH）仍有可能进展为多系统 LCH。在戒烟后 PLCH 病变改善的情况下，可能会出现复发或进展。因此，密切随访至关重要。
