Division of Restorative Dentistry, Department of Ecological Dentistry, Tohoku University Graduate School of Dentistry, Sendai, Miyagi, Japan.
Division of Cardiovascular Surgery, Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan.
BMC Oral Health. 2022 Aug 9;22(1):336. doi: 10.1186/s12903-022-02361-5.
Marfan syndrome (MFS) is a systemic disorder of connective tissues caused by insufficient elastic fiber formation that leads to structural weakness and results in various tissue disorders, including cardiovascular and periodontal disease. Notably however, the risk of periodontal disease in MFS patients affected by an aortic aneurysm or dissection has not yet been clarified.
We investigated the periodontal condition in the following three groups: MFS patients diagnosed with an aortic aneurysm or dissection with a planned aortic surgery (MFS surgery), MFS patients who had already undergone aortic surgery (MFS post-surgery) and healthy control patients (Healthy). The periodontal condition of all of these patients was evaluated at their first visit, reassessed again at two-month after the first visit, and evaluated again at a six-month follow-up after the reassessment.
A total of 14 participants, 3 MFS surgery patients, 4 MFS post-surgery patients and 7 healthy control volunteers were examined. Saliva examinations revealed no significant differences between any of the groups at the first visit, reassessment, or follow-up. Interestingly, the MFS surgery cases showed a higher BOP and PISA at the first visit and follow-up compared with the other groups. In contrast, the MFS surgery patients showed an improvement in their LVDd and EF values, both markers of cardiac function, at the reassessment and follow-up compared with the first visit.
MFS associated with an aortic aneurysm or dissection leads to a higher risk of periodontal disease, indicating the need for more frequent oral hygiene maintenance in these patients. In addition, MFS patients who undergo frequent professional cleaning of their teeth show a lower onset of cardiovascular disease, suggesting that professional oral hygiene in these cases contributes to a healthier condition.
马凡综合征（MFS）是一种结缔组织的全身性疾病，由弹性纤维形成不足引起，导致结构脆弱，从而导致各种组织疾病，包括心血管疾病和牙周病。然而，患有主动脉瘤或夹层的 MFS 患者患牙周病的风险尚未阐明。
我们研究了以下三组人群的牙周状况：计划进行主动脉手术的 MFS 患者（MFS 手术）、已接受过主动脉手术的 MFS 患者（MFS 手术后）和健康对照组患者（健康）。所有这些患者的牙周状况在首次就诊时进行评估，首次就诊后两个月再次评估，并在重新评估后六个月进行随访评估。
共有 14 名参与者，3 名 MFS 手术患者、4 名 MFS 手术后患者和 7 名健康对照组志愿者接受了检查。唾液检查显示，在首次就诊、再次评估或随访时，各组之间没有明显差异。有趣的是，MFS 手术组在首次就诊和随访时的 BOP 和 PISA 均高于其他组。相比之下，MFS 手术组在再次评估和随访时的 LVDd 和 EF 值（心脏功能的两个标志物）均有所改善，与首次就诊时相比。
与主动脉瘤或夹层相关的 MFS 导致牙周病的风险更高，表明这些患者需要更频繁的口腔卫生维护。此外，MFS 患者经常接受专业洁牙，心血管疾病的发病风险较低，这表明在这些情况下进行专业口腔卫生有助于保持更健康的状态。
