Orthodontics, Preventive Dentistry Department, College of Dentistry, Jouf University, Sakaka 72345, Saudi Arabia.
Department of Preventive Dentistry, College of Dentistry in Ar Rass, Qassim University, Ar Rass 52571, Saudi Arabia.
Int J Environ Res Public Health. 2022 Apr 21;19(9):5048. doi: 10.3390/ijerph19095048.
This meta-analysis aimed to compare Marfan syndrome (MFS) patients with non-MFS populations based on orofacial health status to combine publicly available scientific information while also improving the validity of primary study findings. A comprehensive search was performed in the following databases: PubMed, Google Scholar, Scopus, Medline, and Web of Science, for articles published between 1 January 2000 and 17 February 2022. PRISMA guidelines were followed to carry out this systematic review. We used the PECO system to classify people with MFS based on whether or not they had distinctive oral health characteristics compared to the non-MFS population. The following are some examples of how PECO is used: P denotes someone who has MFS; E stands for a medical or genetic assessment of MFS; C stands for people who do not have MFS; and O stands for the orofacial characteristics of MFS. Using the Newcastle-Ottawa Quality Assessment Scale, independent reviewers assessed the articles' methodological quality and extracted data. Four case-control studies were analyzed for meta-analysis. Due to the wide range of variability, we were only able to include data from at least three previous studies. There was a statistically significant difference in bleeding on probing and pocket depth between MFS and non-MFS subjects. MFS patients are more prone to periodontal tissue inflammation due to the activity of FBN1 and MMPs. Early orthodontic treatment is beneficial for the correction of a narrow upper jaw and a high palate, as well as a skeletal class II with retrognathism of the lower jaw and crowding of teeth.
本荟萃分析旨在比较马凡综合征（MFS）患者和非 MFS 人群的口腔健康状况，以合并公开可得的科学信息，同时提高主要研究结果的有效性。在以下数据库中进行了全面搜索：PubMed、Google Scholar、Scopus、Medline 和 Web of Science，以获取 2000 年 1 月 1 日至 2022 年 2 月 17 日期间发表的文章。本系统评价遵循 PRISMA 指南进行。我们使用 PECO 系统根据 MFS 患者是否具有与非 MFS 人群不同的口腔健康特征来对其进行分类。PECO 的使用示例如下：P 表示患有 MFS 的人；E 代表对 MFS 的医学或遗传评估；C 表示没有 MFS 的人；O 表示 MFS 的口腔特征。独立评审员使用纽卡斯尔-渥太华质量评估量表评估了文章的方法学质量并提取了数据。对四项病例对照研究进行了荟萃分析。由于变异性很大，我们只能纳入至少三项先前研究的数据。MFS 和非 MFS 受试者之间在探诊出血和牙周袋深度方面存在统计学显著差异。由于 FBN1 和 MMPs 的活性，MFS 患者更容易发生牙周组织炎症。早期正畸治疗有利于对上颌狭窄和高腭的矫正，以及下颌后缩和牙齿拥挤的骨骼 II 类。
