People's Hospital of Longhua, Shenzhen, China.
Department of Photodynamic, Medical Laser Research Center, Yara Institute, ACECR, Tehran, Iran.
J Food Biochem. 2022 Oct;46(10):e14358. doi: 10.1111/jfbc.14358. Epub 2022 Aug 9.
Owing to its prevalent nature, diabetes mellitus has become one of the most serious endocrine illnesses affecting a patient's quality of life due to the manifestation of side effects such as cardiovascular diseases, retinopathy, neuropathy, and nephropathy. Curcumin ((1E, 6E) 21, 7-bis (4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione), a major compound of turmeric, has been used in conventional medicine because of its safe nature and cost-effectiveness to meliorate diabetes and its comorbidities. These effects have also been observed in rodent models of diabetes resulting in a reduction of glycemia and blood lipids. Both the preventive and therapeutic activities of this compound are due to its antioxidant and anti-inflammatory characteristics. Furthermore, preclinical outcomes and clinical investigation demonstrate that the use of curcumin neutralizes insulin resistance, obesity, and hyperglycemia. Despite the many benefits of curcumin, its two limiting factors, solubility and bioavailability, remain a challenge for researchers; therefore, several methods such as drug formulation, nano-drug delivery, and the use of curcumin analogs have been developed to deliver curcumin and increase its bioavailability. PRACTICAL APPLICATIONS: The rise of people with type 2 diabetes has become a major concern at the global healthcare level. The best diabetes treatments today are anti-diabetic drug administration, lifestyle-related interventions (such as healthy eating and daily physical activity), arterial pressure detection, and fat control. The polyphenol curcumin, found in turmeric, can promote health by acting on a variety of cellular signaling pathways. This review article discusses curcumin and its role in the treatment of diabetes.
由于糖尿病的普遍存在，由于心血管疾病、视网膜病变、神经病变和肾病等副作用的表现，它已成为影响患者生活质量的最严重的内分泌疾病之一。姜黄素（（1E，6E）21，7-双（4-羟基-3-甲氧基苯基）-1,6-庚二烯-3,5-二酮），是姜黄的主要化合物，由于其性质安全且具有成本效益，已被用于常规医学中，以改善糖尿病及其合并症。在糖尿病啮齿动物模型中也观察到这些效果，导致血糖和血脂降低。这种化合物的预防和治疗作用都归因于其抗氧化和抗炎特性。此外，临床前结果和临床研究表明，姜黄素的使用可以中和胰岛素抵抗、肥胖和高血糖。尽管姜黄素有许多好处，但它的两个限制因素，溶解度和生物利用度，仍然是研究人员面临的挑战；因此，已经开发了几种方法，如药物配方、纳米药物递送和使用姜黄素类似物，以输送姜黄素并提高其生物利用度。实际应用：2 型糖尿病患者的增加已成为全球医疗保健层面的主要关注点。当今最好的糖尿病治疗方法是服用抗糖尿病药物、进行与生活方式相关的干预（如健康饮食和日常体育活动）、检测动脉压和控制脂肪。姜黄中的多酚类姜黄素可以通过作用于多种细胞信号通路来促进健康。本文综述了姜黄素及其在糖尿病治疗中的作用。
