Department of Periodontology, Faculty of Dental Sciences, Institute of Medical Sciences, BHU, Uttar Pradesh, India.
Department of Conservative Dentistry and Endodontics, Faculty of Dental Sciences, Institute of Medical Sciences, BHU, Uttar Pradesh, India.
Indian J Dent Res. 2022 Jan-Mar;33(1):41-45. doi: 10.4103/ijdr.ijdr_912_21.
Reactive oxygen species released on stimulation by periodontal pathogens cause oxidation of biomolecules and play significant role in periodontal disease pathogenesis.
This study aimed to evaluate the levels of oxidative by-products malondialdehyde (MDA) and 8-hydroxy deoxyguanosine (8-OHdG) as biomarkers in chronic periodontitis patients compared to healthy as well as before and after nonsurgical periodontal therapy. The correlation between biomarkers and clinical attachment level was also evaluated.
A total of 112 subjects were included in this study. The subjects were divided into two groups (Group I included 56 healthy subjects and Group II constituted 56 chronic periodontitis patients) on the basis of clinical periodontal parameters.
Group I subjects received no treatment and were evaluated once only for clinical and oxidative stress biomarker parameters. Nonsurgical periodontal therapy was carried out in Group II patients and they were evaluated at baseline and 3 months after therapy.
Both salivary and serum levels of MDA and 8-OHdG were found to be increased in chronic periodontitis patients as compared to healthy subjects. After nonsurgical periodontal therapy, the levels of MDA and 8-OHdG significantly reduced. Linear correlation between clinical attachment level and oxidative stress parameters was found to be positive and highly significant.
It can be concluded that periodontal therapy is effective in improving the oxidative stress condition.
牙周病病原体刺激释放的活性氧会导致生物分子氧化，在牙周病发病机制中起重要作用。
本研究旨在评估慢性牙周炎患者与健康者、牙周非手术治疗前后氧化生物标志物丙二醛（MDA）和 8-羟基脱氧鸟苷（8-OHdG）的水平。还评估了生物标志物与临床附着水平之间的相关性。
本研究共纳入 112 名受试者。根据临床牙周参数，将受试者分为两组（第 I 组包括 56 名健康受试者，第 II 组由 56 名慢性牙周炎患者组成）。
第 I 组受试者未接受任何治疗，仅评估一次临床和氧化应激生物标志物参数。对第 II 组患者进行牙周非手术治疗，并在基线和治疗后 3 个月进行评估。
与健康受试者相比，慢性牙周炎患者的唾液和血清 MDA 和 8-OHdG 水平均升高。牙周非手术治疗后，MDA 和 8-OHdG 水平显著降低。临床附着水平与氧化应激参数之间呈正相关，且具有高度显著性。
牙周治疗可有效改善氧化应激状况。
