Science Health Institute, Universidad Veracruzana, Veracruz, México.
Clinical and Translational Research Department, Science Health Institute, Universidad Veracruzana, St. Dr. Luis Castelazo Ayala s/n, Col. Industrial Ánimas, Xalapa, Veracruz, CP 91190, México.
BMC Oral Health. 2024 Aug 4;24(1):892. doi: 10.1186/s12903-024-04688-7.
Periodontal Disease (PD) associated with Type 2 Diabetes Mellitus (T2DM) is a chronic condition that affects the oral cavity of people living with T2DM. The mechanisms of the interaction between type 2 Diabetes Mellitus and Periodontal diseases are complex and involve multiple pathophysiological pathways related to the systemic inflammatory process and oxidative stress. Non-surgical periodontal treatment (NSTP) is considered the standard for the management of this disease; however, patients with systemic conditions such as type 2 Diabetes Mellitus do not seem to respond adequately. For this reason, the use of complementary treatments has been suggested to support non-surgical periodontal treatment to reduce the clinical consequences of the disease and improve the systemic conditions of the patient. The use of zinc gluconate and magnesium oxide as an adjunct to non-surgical periodontal treatment and its effects on periodontal clinical features and oxidative stress in patients with Periodontal diseases -type 2 Diabetes Mellitus is poorly understood.
A quasi-experimental study was performed in patients with periodontal diseases associated with T2DM. Initially, 45 subjects who met the selection criteria were included. 19 were assigned to a control group [non-surgical periodontal treatment] and 20 to the experimental group (non-surgical periodontal treatment + 500 mg of magnesium oxide and 50 mg of zinc gluconate for oral supplementation for 30 days) and the data of 6 patients were eliminated. Sociodemographic characteristics, physiological factors, biochemical parameters, and clinical features of periodontal diseases were assessed.
In this research a change in periodontal clinical characteristics was observed, which has been associated with disease remission. Additionally, a shift in MDA levels was presented for both groups. Furthermore, the supplementation group showed an increase in antioxidant enzymes when compared to the group that only received NSPT.
The use of Zinc gluconate and magnesium oxide can serve as a complementary treatment to non-surgical periodontal treatment, that supports the remission of PD as a result of regulation-reduction of oxidative biomarkers and increase in antioxidant enzymes activity.
https://www.isrctn.com ISRCTN 14,092,381. September 13º 2023. Retrospective Registration.
与 2 型糖尿病（T2DM）相关的牙周病（PD）是一种影响 T2DM 患者口腔的慢性疾病。2 型糖尿病与牙周病之间相互作用的机制复杂，涉及与全身炎症过程和氧化应激相关的多种病理生理途径。非手术性牙周治疗（NSTP）被认为是治疗这种疾病的标准方法；然而，患有 2 型糖尿病等系统性疾病的患者似乎反应不充分。出于这个原因，已经建议使用补充治疗来支持非手术性牙周治疗，以减轻疾病的临床后果并改善患者的全身状况。将葡萄糖酸锌和氧化镁用作非手术性牙周治疗的辅助手段，及其对患有牙周病-2 型糖尿病患者的牙周临床特征和氧化应激的影响知之甚少。
在患有 T2DM 相关牙周病的患者中进行了一项准实验研究。最初，纳入了符合选择标准的 45 名受试者。19 名被分配到对照组[非手术性牙周治疗]，20 名被分配到实验组（非手术性牙周治疗+口服 500mg 氧化镁和 50mg 葡萄糖酸锌补充剂 30 天），并排除了 6 名患者的数据。评估了社会人口统计学特征、生理因素、生化参数和牙周病的临床特征。
在这项研究中观察到牙周临床特征的变化，这与疾病缓解有关。此外，两组的 MDA 水平也发生了变化。此外，与仅接受 NSPT 的组相比，补充组的抗氧化酶水平增加。
葡萄糖酸锌和氧化镁的使用可以作为非手术性牙周治疗的补充治疗，通过调节氧化生物标志物的减少和抗氧化酶活性的增加来支持 PD 的缓解。
https://www.isrctn.com ISRCTN 14,092,381. September 13, 2023. 回顾性注册。
