Universidade Federal Fluminense, Departamento de Neurologia, Unidade de Pesquisa Clínica, Niterói RJ, Brazil.
Universidade Federal do Estado do Rio de Janeiro, Departamento de Neurologia, Unidade de Pesquisa Clínica, Niterói RJ, Brazil.
Arq Neuropsiquiatr. 2022 Jun;80(6):607-615. doi: 10.1590/0004-282X-ANP-2021-0079.
After the advent of combination antiretroviral therapy, infection with the human immunodeficiency virus (HIV) ceased to be a devastating disease, but sensory neuropathy resulting from the permanence of the virus and the side effects of treatment have worsened the morbidities of these patients.
To investigate the quality of life of 64 HIV-positive patients: 24 with painful neuropathy (case group) and 40 without painful neuropathy (control group). The impact of other factors on quality of life was also assessed.
To assess painful neuropathy, the Leeds Assessment of Neuropathic Symptoms and Signs (LANSS) scale, Douleur Neuropathique 4 (DN4) questions and Neuropathy Disability Score (NDS) were used. The Short Form Health Survey (SF-36) scale was used to assess quality of life. Factors related or unrelated to HIV were obtained through the medical history and analysis on medical records.
The quality of life of patients with neuropathic pain was worse in six of the eight domains of the SF-36 scale. The number of clinical manifestations related to HIV, length of time with detectable viral load since diagnosis, length of time since the diagnosis of HIV infection and length of time of HAART use had a negative impact on quality of life. Higher levels of CD4, education and family income had a positive impact.
Painful neuropathy related to HIV is a factor that worsens the quality of life of patients infected with this virus and should be included in the clinical evaluation.
抗逆转录病毒联合疗法问世后，人类免疫缺陷病毒（HIV）感染不再是一种毁灭性疾病，但病毒的持续存在和治疗的副作用导致的感觉神经病变使这些患者的发病率恶化。
调查 64 例 HIV 阳性患者的生活质量：24 例有疼痛性神经病变（病例组）和 40 例无疼痛性神经病变（对照组）。还评估了其他因素对生活质量的影响。
使用 Leeds 评估感觉神经病变症状和体征（LANSS）量表、DN4 问题和神经病变残疾评分（NDS）评估疼痛性神经病变。使用简明健康调查量表（SF-36）量表评估生活质量。通过病史和病历分析获得与 HIV 相关或不相关的因素。
在 SF-36 量表的八个领域中，有六个领域的神经病变疼痛患者的生活质量更差。与 HIV 相关的临床表现数量、自诊断以来可检测到的病毒载量时间、HIV 感染诊断时间和 HAART 使用时间长短对生活质量有负面影响。较高的 CD4 水平、教育程度和家庭收入有积极影响。
与 HIV 相关的疼痛性神经病变是恶化感染这种病毒的患者生活质量的一个因素，应纳入临床评估。
