Benevides Maria Luiza Areal Corrêa de Sá E, Filho Sérgio Beduschi, Debona Rodrigo, Bergamaschi Eduardo Novaes Costa, Nunes Jean Costa
Division of Neuropathology, Universidade Federal de Santa Catarina (UFSC), Rua Professora Maria Flora Pausewang, Trindade, Florianópolis, Santa Catarina (SC), Brazil.
Hospital Nereu Ramos (HNR), Rua Rui Barbosa, Agronômica, Florianópolis, Santa Catarina (SC), Brazil.
J Neurol Sci. 2017 Apr 15;375:316-320. doi: 10.1016/j.jns.2017.02.011. Epub 2017 Feb 8.
The progress on HIV infection treatment has allowed a longer survival for HIV-infected patients. However, chronic comorbidities are emerging. Peripheral Neuropathy (PN) represents one of the most prevalent neurologic disorders among these patients, and comprehensive studies may contribute to a reduction in the morbidity of this condition. This is a cross-sectional analytic study conducted in a tertiary referral hospital in southern Brazil. This study investigates the prevalence of PN among HIV-infected patients and associated demographic, clinical and laboratory variables. A number of 150 HIV-infected patients admitted between January and May 2016 were interviewed, submitted to physical and neurological examination, and data from their medical records were obtained. The prevalence of PN was 31.3%. It was increased among older patients (p=0.02), patients with higher CD4 lymphocytes levels (p=0.02), and smokers (OR=3.4; 95% CI 1.6-6.9; p<0.01). The research identified a high prevalence of PN in HIV-infected patients. Older age and higher CD4 levels have been associated with PN. To the best of our knowledge, this was one of the first studies reporting an association between tobacco use and PN among HIV-infected patients. Further studies are necessary to elucidate the pathological mechanisms linking PN and tobacco.
艾滋病病毒（HIV）感染治疗方面的进展使HIV感染患者的生存期得以延长。然而，慢性合并症正不断出现。周围神经病变（PN）是这些患者中最常见的神经疾病之一，全面的研究可能有助于降低这种疾病的发病率。这是一项在巴西南部一家三级转诊医院开展的横断面分析研究。本研究调查了HIV感染患者中PN的患病率以及相关的人口统计学、临床和实验室变量。对2016年1月至5月期间收治的150例HIV感染患者进行了访谈，对其进行了体格和神经学检查，并获取了他们病历中的数据。PN的患病率为31.3%。在老年患者（p=0.02）、CD4淋巴细胞水平较高的患者（p=0.02）和吸烟者中（比值比=3.4；95%置信区间1.6 - 6.9；p<0.01），PN患病率有所增加。该研究发现HIV感染患者中PN的患病率较高。年龄较大和CD4水平较高与PN有关。据我们所知，这是首批报告HIV感染患者中吸烟与PN之间存在关联的研究之一。有必要开展进一步研究以阐明PN与烟草之间的病理机制。
