高效抗逆转录病毒治疗是否会使 HIV 感染性先兆子痫中的血管生成失调？

Does HAART dysregulate angiogenesis in HIV infected preeclampsia?

机构信息

Discipline of Optics and Imaging, Doris Duke Medical Research Institute, College of Health Sciences, University of KwaZulu-Natal, Durban, KwaZulu-Natal, South Africa, 4001.

Department of Basic Medical Sciences, Faculty of Health Sciences, Durban University of Technology, Durban, South Africa.

出版信息

Niger J Physiol Sci. 2022 Jun 30;37(1):29-34. doi: 10.54548/njps.v36i2.4.

DOI:10.54548/njps.v36i2.4

PMID:35947837

Abstract

A dysregulation of angiogenic mediators has been implicated in HIV infection. Inconsistent data exists on highly active antiretroviral therapy (HAART) usage in pregnancy and its association with PE development. In view of the high prevalence of HIV infection and PE in SA, this study was aimed at determining PlGF and sFlt-1 levels in HIV-infected normotensive and preeclamptic pregnancies treated with HAART. Both PlGF and sFlt-1 were quantified in serum from HIV positive [normotensive (N+) and preeclamptic (P+)]; and HIV negative [normotensive (N-) and preeclamptic (P-)] pregnancies, using a Milliplex Multiplex immunoassay. sFlt-1 was significantly upregulated in P+ vs the N+ groups. PlGF was significantly downregulated in PE vs normotensive groups, regardless of HIV status. sFlt-1/PlGF ratio was significantly increased in PE- vs the N- groups. We report an amplification of sFlt-1 in lieu of PlGF down-regulation in HIV-infected pregnancies receiving HAART .

摘要

血管生成介质的失调已被认为与 HIV 感染有关。关于高效抗逆转录病毒疗法 (HAART) 在妊娠中的应用及其与 PE 发展的关系，存在不一致的数据。鉴于南非 HIV 感染和 PE 的高患病率，本研究旨在确定接受 HAART 治疗的 HIV 感染正常血压和子痫前期妊娠中的 PlGF 和 sFlt-1 水平。使用 Milliplex Multiplex 免疫测定法，从 HIV 阳性[正常血压 (N+)和子痫前期 (P+)]和 HIV 阴性[正常血压 (N-)和子痫前期 (P-)]妊娠的血清中定量测定 PlGF 和 sFlt-1。与 N+组相比，P+组 sFlt-1 显著上调。PE 组 PlGF 明显低于正常血压组，与 HIV 状态无关。PE-与 N-组相比，sFlt-1/PlGF 比值显著升高。我们报告了在接受 HAART 的 HIV 感染妊娠中，sFlt-1 的扩增代替了 PlGF 的下调。