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文献综述：sFlt1/PlGF 比值与孕前母体合并症：预测子痫前期的新危险因素。

Literature Review: The sFlt1/PlGF Ratio and Pregestational Maternal Comorbidities: New Risk Factors to Predict Pre-Eclampsia.

机构信息

Federal State Budgetary Institution "Research Institute of Pathology and Pathophysiology", St. Baltiyskaya, House 8, Moscow 125315, Russia.

State Budgetary Health Institution of the Moscow Region "Moscow Regional Research Institute of Obstetrics and Gynecology", St. Pokrovka, d.22a, Moscow 101000, Russia.

出版信息

Int J Mol Sci. 2023 Apr 4;24(7):6744. doi: 10.3390/ijms24076744.

DOI:10.3390/ijms24076744
PMID:37047717
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10095124/
Abstract

One of the main causes of maternal and neonatal morbidity and mortality is pre-eclampsia. It is characterized by a high sFlt1/PlGF ratio, according to prior research. Pregestational diseases in mothers may increase the risk of developing pre-eclampsia. Only a few studies have looked at the connection between maternal comorbidities before conception and the sFlt1/PlGF ratio. The most recent information regarding the association between maternal pregestational diseases and the ratio of sFlt1/PlGF is described in this review. The paper also examines current research suggesting that changes in pregnancy hormones and metabolites are related to a high sFlt1/PlGF ratio. Certain maternal disorders have been found to dramatically raise sFlt-1 and sFlt1/PlGF levels, according to an analysis of the literature. There is still debate about the data on the association between the sFlt1/PlGF ratio and maternal disorders such as HIV, acute coronary syndromes, cardiovascular function in the mother between 19 and 23 weeks of pregnancy, thyroid hormones, diabetes, and cancer. Additional research is needed to confirm these findings.

摘要

子痫前期是导致孕产妇和新生儿发病率和死亡率的主要原因之一。根据之前的研究，它的特征是 sFlt1/PlGF 比值高。母亲的孕前疾病可能会增加发生子痫前期的风险。只有少数研究探讨了母亲孕前合并症与 sFlt1/PlGF 比值之间的关系。本综述描述了关于母体孕前疾病与 sFlt1/PlGF 比值之间关联的最新信息。本文还研究了目前的研究结果，表明妊娠激素和代谢物的变化与 sFlt1/PlGF 比值升高有关。根据文献分析，某些母体疾病被发现可显著升高 sFlt-1 和 sFlt1/PlGF 水平。关于 sFlt1/PlGF 比值与 HIV、急性冠脉综合征、母亲妊娠 19 至 23 周时的心血管功能、甲状腺激素、糖尿病和癌症等母体疾病之间关联的数据仍存在争议。需要进一步的研究来证实这些发现。

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