Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA.
Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA.
Immunity. 2022 Aug 9;55(8):1334-1336. doi: 10.1016/j.immuni.2022.07.009.
In this issue of Immunity, Bi et al. identify a microglia-neuron signaling axis that is critical for maintaining central control of the sympathetic nervous system. They find that platelet growth factor B released by microglia acts on neurons via PDGFRα to regulate sympathetic outflow. Disrupting this pathway leads to neuronal excitability, highlighting a promising therapeutic target to modulate sympathetic outflow and reduce hypertension.
在本期《免疫》中，Bi 等人确定了一个小胶质细胞-神经元信号轴，该信号轴对于维持交感神经系统的中枢控制至关重要。他们发现小胶质细胞释放的血小板生长因子 B 通过 PDGFRα 作用于神经元，从而调节交感神经输出。破坏这条通路会导致神经元兴奋性增加，这突出了一个有希望的治疗靶点，可以调节交感神经输出并降低高血压。
