Arranz Peña M I, Saenz Lope E
Clin Chem. 1987 Jun;33(6):812-3.
Using fluorescence polarization immunoassay, we measured the peak and trough concentrations of total and free carbamazepine in serum and saliva from 33 epileptic children. We found that, except for patients who show side effects, measurement of trough values in a single sample, collected after an overnight fast and before the morning dose, sufficiently estimates clinical response. Moreover, total carbamazepine is as informative as free carbamazepine.
我们采用荧光偏振免疫分析法，测定了33例癫痫患儿血清和唾液中总卡马西平和游离卡马西平的峰浓度和谷浓度。我们发现，除了出现副作用的患者外，在禁食过夜后、晨服药物前采集的单一样本中测定谷值，足以评估临床反应。此外，总卡马西平和游离卡马西平提供的信息一样多。
