唾液中卡马西平和苯妥英水平监测。
Saliva carbamazepine and phenytoin level monitoring.
作者信息
Rylance G W, Moreland T A
出版信息
Arch Dis Child. 1981 Aug;56(8):637-40. doi: 10.1136/adc.56.8.637.
Abstract
Saliva carbamazepine and phenytoin samples were used to monitor treatment in 35 children aged between 2 and 14 years during a 2-year period. All phenytoin levels and over half the carbamazepine levels that were above the therapeutic range were associated with adverse effects. Dose and carbamazepine saliva levels were significantly related but no such relationship was found for phenytoin. There was no apparent relationship between the saliva level of either drug and convulsion control.
摘要
在两年的时间里，收集了35名年龄在2至14岁儿童的唾液卡马西平和苯妥英样本，用于监测治疗情况。所有高于治疗范围的苯妥英水平以及超过一半的卡马西平水平都与不良反应相关。剂量与卡马西平唾液水平显著相关，但未发现苯妥英有此类关系。两种药物的唾液水平与惊厥控制之间均无明显关系。
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