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COVID-19 大流行演变中的不平等现象:对第一波死亡率不平等现象及英格兰首次全国封锁影响的生态学研究。

Inequalities in the evolution of the COVID-19 pandemic: an ecological study of inequalities in mortality in the first wave and the effects of the first national lockdown in England.

机构信息

Population Health Sciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK

Population Health Sciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK.

出版信息

BMJ Open. 2022 Aug 10;12(8):e058658. doi: 10.1136/bmjopen-2021-058658.

Abstract

OBJECTIVES

To examine how ecological inequalities in COVID-19 mortality rates evolved in England, and whether the first national lockdown impacted them. This analysis aimed to provide evidence for important lessons to inform public health planning to reduce inequalities in any future pandemics.

DESIGN

Longitudinal ecological study.

SETTING

307 lower-tier local authorities in England.

PRIMARY OUTCOME MEASURE

Age-standardised COVID-19 mortality rates by local authority, regressed on Index of Multiple Deprivation (IMD) and relevant epidemic dynamics.

RESULTS

Local authorities that started recording COVID-19 deaths earlier were more deprived, and more deprived authorities saw faster increases in their death rates. By 6 April 2020 (week 15, the earliest time that the 23 March lockdown could have begun affecting death rates) the cumulative death rate in local authorities in the two most deprived deciles of IMD was 54% higher than the rate in the two least deprived deciles. By 4 July 2020 (week 27), this gap had narrowed to 29%. Thus, inequalities in mortality rates by decile of deprivation persisted throughout the first wave, but reduced during the lockdown.

CONCLUSIONS

This study found significant differences in the dynamics of COVID-19 mortality at the local authority level, resulting in inequalities in cumulative mortality rates during the first wave of the pandemic. The first lockdown in England was fairly strict-and the study found that it particularly benefited those living in more deprived local authorities. Care should be taken to implement lockdowns early enough, in the right places-and at a sufficiently strict level-to maximally benefit all communities, and reduce inequalities.

摘要

目的

研究英格兰 COVID-19 死亡率的生态不平等现象是如何演变的,以及第一次全国封锁是否对其产生了影响。本分析旨在为提供重要经验教训提供证据,以指导公共卫生规划,减少未来任何大流行中的不平等现象。

设计

纵向生态研究。

地点

英格兰 307 个低级别地方当局。

主要结果衡量标准

按地方当局划分的年龄标准化 COVID-19 死亡率,回归到多因素贫困指数(IMD)和相关的疫情动态。

结果

较早开始记录 COVID-19 死亡人数的地方当局越贫困,死亡率增长越快。到 2020 年 4 月 6 日(第 15 周,最早 3 月 23 日的封锁可能开始影响死亡率的时间),在 IMD 最贫困的两个十分位数的地方当局的累积死亡率比最不贫困的两个十分位数高出 54%。到 2020 年 7 月 4 日(第 27 周),这一差距缩小到 29%。因此,在整个第一波疫情期间,按贫困程度十分位数划分的死亡率不平等现象持续存在,但在封锁期间有所减少。

结论

本研究发现 COVID-19 死亡率在地方当局层面存在显著差异,导致大流行第一波期间累积死亡率不平等。英格兰的第一次封锁相当严格,研究发现它特别使那些生活在较贫困地方当局的人受益。应注意在适当的地方及早实施封锁,并且以足够严格的水平进行,以使所有社区受益最大化,并减少不平等现象。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b4e9/9378950/c6caf0b56989/bmjopen-2021-058658f01.jpg

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