血清白细胞介素-38 水平与非酒精性脂肪性肝病中的胰岛素抵抗、肝损伤和脂质相关。
Serum interleukin-38 levels correlated with insulin resistance, liver injury and lipids in non-alcoholic fatty liver disease.
机构信息
Department of Biochemistry and Molecular Biology, School of Medicine, Jiujiang University, 17# Lufeng Road, Jiujiang, 332000, Jiangxi Province, China.
Department of Clinical Laboratory, Jiujiang NO.1 People's Hospital, 48# The South of Taling Road, Jiujiang, 332000, Jiangxi Province, China.
出版信息
Lipids Health Dis. 2022 Aug 10;21(1):70. doi: 10.1186/s12944-022-01676-0.
BACKGROUND
Insulin resistance, liver injury and dyslipidemia are reported in non-alcoholic fat liver disease (NAFLD) patients. Interleukin (IL)-38 may take part in the pathophysiology of insulin resistance. Nevertheless, the function of IL-38 in NAFLD is unknown. Herein, we determined whether serum IL-38 level might be utilised as a biochemical marker for diagnosing NAFLD.
METHODS
NAFLD patients and healthy participants (n = 91 each) were enrolled. Circulating serum IL-38 levels were detected using enzyme-linked immunosorbent assay. Other metabolic and inflammatory indices related to NAFLD were also assessed.
RESULTS
Patients with NAFLD had higher serum IL-38 levels than healthy individuals. Significantly higher serum IL-38 levels were found in patients with severe and moderate NAFLD than in patients with mild NAFLD. IL-38 showed a significant correlation with parameters of insulin resistance, inflammation, and liver enzyme in NAFLD cases. Anthropometric, insulin resistance, inflammatory parameters, lipids and frequency of NAFLD showed significant differences among the serum IL-38 level tertiles. Participants in the 2nd and 3rd tertiles of serum IL-38 levels had a greater risk of NAFLD than those in the 1st tertile. Furthermore, IL-38 ROC curve showed a high area under ROC with 0.861.
CONCLUSIONS
It is possible for serum IL-38 to be a biomarker for NAFLD.
背景
胰岛素抵抗、肝损伤和血脂异常在非酒精性脂肪性肝病（NAFLD）患者中均有报道。白细胞介素（IL）-38可能参与胰岛素抵抗的病理生理学过程。然而，IL-38在 NAFLD 中的作用尚不清楚。在此，我们确定血清 IL-38 水平是否可作为诊断 NAFLD 的生化标志物。
方法
纳入 91 例 NAFLD 患者和 91 例健康对照者。采用酶联免疫吸附试验检测循环血清 IL-38 水平。同时评估与 NAFLD 相关的其他代谢和炎症指标。
结果
与健康对照者相比，NAFLD 患者血清 IL-38 水平更高。中、重度 NAFLD 患者的血清 IL-38 水平明显高于轻度 NAFLD 患者。IL-38 与 NAFLD 患者的胰岛素抵抗、炎症和肝酶参数呈显著相关。血清 IL-38 水平三分位组间的人体测量学、胰岛素抵抗、炎症参数、血脂以及 NAFLD 频率均存在显著差异。血清 IL-38 水平处于第 2 分位和第 3 分位的患者发生 NAFLD 的风险高于第 1 分位。此外，IL-38 的 ROC 曲线显示其具有 0.861 的高 ROC 曲线下面积。
结论
血清 IL-38 可能成为 NAFLD 的一种生物标志物。
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