Sakurai Yasuhisa, Mannen Toru
Department of Neurology, Mitsui Memorial Hospital, Tokyo, Japan.
Case Rep Neurol. 2022 Jun 30;14(2):296-306. doi: 10.1159/000525254. eCollection 2022 May-Aug.
We herein report the case of a patient who showed pure anomia and amnesia caused by hemorrhage in the left thalamus, involving the anterior, ventral anterior, and mediodorsal nuclei. It was revealed that the anomia was characterized by impaired retrieval of object names, which was more pronounced in artificial objects, and abundant perseveration, whereas the amnesia was mild and limited to daily routine events, which was made clear from the results of an episodic memory scale. Detailed lesion localization and literature review revealed that a combination of pure anomia and amnesia can occur in a lesion involving the anterior, ventral anterior, or mediodorsal nucleus of the thalamus. The relative specificity to artificial objects can be explained by the locally damaged fiber connection to the putative category-specific lexical area in the temporal lobe.
我们在此报告一例患者，其因左侧丘脑出血，累及丘脑前核、腹前核和背内侧核，出现了单纯性命名障碍和遗忘症。结果显示，命名障碍的特征为物体名称提取受损，在人造物体方面更为明显，且存在大量持续性错误；而遗忘症较轻，仅限于日常事件，这从情景记忆量表的结果中得以明确。详细的病变定位及文献回顾表明，单纯性命名障碍和遗忘症的组合可发生于累及丘脑前核、腹前核或背内侧核的病变中。对人造物体的相对特异性可通过与颞叶假定的类别特异性词汇区域局部受损的纤维连接来解释。
