丘脑在语言中的作用机制：基于近期研究发现和理论的再思考。
Thalamic mechanisms in language: a reconsideration based on recent findings and concepts.
机构信息
VA RR&D Center of Excellence (151R), Atlanta VA Medical Center, Decatur, GA 30033, USA.
出版信息
Brain Lang. 2013 Jul;126(1):73-88. doi: 10.1016/j.bandl.2012.06.011. Epub 2012 Jul 23.
Abstract
Recent literature on thalamic aphasia and thalamic activity during neuroimaging is selectively reviewed followed by a consideration of recent anatomic and physiological findings regarding thalamic structure and functions. It is concluded that four related corticothalamic and/or thalamocortical mechanisms impact language processing: (1) selective engagement of task-relevant cortical areas in a heightened state of responsiveness in part through the nucleus reticularis (NR), (2) passing information from one cortical area to another through corticothalamo-cortical mechanisms, (3) sharpening the focus on task-relevant information through corticothalamo-cortical feedback mechanisms, and (4) selection of one language unit over another in the expression of a concept, accomplished in concert with basal ganglia loops. The relationship and interaction of these mechanisms is discussed and integrated with thalamic aphasia and neuroimaging data into a theory of thalamic functions in language.
摘要
本文选择性地回顾了近期关于丘脑性失语症和神经影像学期间的丘脑活动的文献，接着考虑了关于丘脑结构和功能的近期解剖学和生理学发现。结论认为，有四个相关的皮质丘脑和/或丘脑皮质机制影响语言处理：（1）通过网状核（NR）部分选择性地参与处于高度反应状态的任务相关皮质区域；（2）通过皮质丘脑皮质机制将信息从一个皮质区域传递到另一个皮质区域；（3）通过皮质丘脑皮质反馈机制使任务相关信息更加集中；（4）在表达概念时选择一个语言单位而不是另一个语言单位，与基底神经节回路协同完成。讨论了这些机制的关系和相互作用，并将其与丘脑性失语症和神经影像学数据整合到语言的丘脑功能理论中。
相似文献
1
Thalamic mechanisms in language: a reconsideration based on recent findings and concepts.丘脑在语言中的作用机制：基于近期研究发现和理论的再思考。
Brain Lang. 2013 Jul;126(1):73-88. doi: 10.1016/j.bandl.2012.06.011. Epub 2012 Jul 23.
2
Thalamus and Language: What do we know from vascular and degenerative pathologies.丘脑与语言：我们从血管性和退行性病变中了解到了什么。
Neurol India. 2018 May-Jun;66(3):772-778. doi: 10.4103/0028-3886.232283.
3
Subcortical functions in language: a working model.语言中的皮层下功能：一个工作模型。
Brain Lang. 1985 Jul;25(2):257-92. doi: 10.1016/0093-934x(85)90085-9.
4
Functional anatomy of thalamus and basal ganglia.丘脑与基底神经节的功能解剖学
Childs Nerv Syst. 2002 Aug;18(8):386-404. doi: 10.1007/s00381-002-0604-1. Epub 2002 Jul 26.
5
The cortico-basal ganglia integrative network: the role of the thalamus.皮质-基底神经节整合网络：丘脑的作用。
Brain Res Bull. 2009 Feb 16;78(2-3):69-74. doi: 10.1016/j.brainresbull.2008.09.013. Epub 2008 Oct 23.
6
Subcortical mechanisms in language: lexical-semantic mechanisms and the thalamus.语言中的皮层下机制：词汇语义机制与丘脑
Brain Cogn. 1999 Jul;40(2):414-38. doi: 10.1006/brcg.1999.1088.
7
Frontal-thalamic circuits associated with language.与语言相关的额-丘脑回路。
Brain Lang. 2013 Jul;126(1):49-61. doi: 10.1016/j.bandl.2012.10.001. Epub 2012 Dec 1.
8
Thalamic interaction between the input and the output systems of the basal ganglia.基底神经节输入与输出系统之间的丘脑相互作用。
J Chem Neuroanat. 1999 May;16(3):187-200. doi: 10.1016/s0891-0618(99)00010-1.
9
The thalamus and language revisited.重新探讨丘脑与语言的关系。
Brain Lang. 2013 Jul;126(1):99-108. doi: 10.1016/j.bandl.2012.06.010. Epub 2012 Aug 2.
10
The place of the thalamus in frontal cortical-basal ganglia circuits.丘脑在额叶皮质-基底神经节回路中的位置。
Neuroscientist. 2001 Aug;7(4):315-24. doi: 10.1177/107385840100700408.
引用本文的文献
1
Impact of White Matter Hyperintensities on Nonverbal Cognition Through Structural Disconnections in Poststroke Aphasia.白质高信号通过卒中后失语症中的结构连接中断对非语言认知的影响。
Stroke. 2025 Jun;56(6):1471-1482. doi: 10.1161/STROKEAHA.124.049058. Epub 2025 Apr 3.
2
Executive Functions Training Improves Language Abilities in Aphasia Rehabilitation: A Systematic Review.执行功能训练改善失语症康复中的语言能力：一项系统综述。
J Pers Med. 2025 Feb 27;15(3):92. doi: 10.3390/jpm15030092.
3
Neural adaptations in short-term learning of sign language revealed by fMRI and DTI.功能磁共振成像（fMRI）和弥散张量成像（DTI）揭示的手语短期学习中的神经适应性
Sci Rep. 2025 Feb 13;15(1):5345. doi: 10.1038/s41598-024-84468-z.
4
Neural correlates of auditory comprehension and integration of sanskrit verse: a functional MRI study.梵文诗句听觉理解与整合的神经关联：一项功能磁共振成像研究。
Brain Struct Funct. 2025 Jan 9;230(1):28. doi: 10.1007/s00429-025-02892-x.
5
Frequency-specific cortico-subcortical interaction in continuous speaking and listening.连续说话和倾听过程中频率特异性的皮质-皮质下相互作用。
Elife. 2024 Dec 23;13:RP97083. doi: 10.7554/eLife.97083.
6
The hypointense pulvinar sign on susceptibility weighed magnetic resonance imaging: A visual biomarker for iron deposition in epilepsy.磁共振成像磁敏感加权像上的丘脑枕低信号征：癫痫中铁沉积的一种可视化生物标志物。
Neuroradiol J. 2025 Jun;38(3):337-345. doi: 10.1177/19714009241303050. Epub 2024 Dec 2.
7
Structure-function interrelationships and associated neurotransmitter profiles in drug-naïve benign childhood epilepsy with central-temporal spikes patients.初发的伴有中央颞区棘波的儿童良性癫痫患者的结构-功能相互关系及相关神经递质谱
Eur Radiol. 2025 Jan;35(1):417-426. doi: 10.1007/s00330-024-10954-7. Epub 2024 Jul 16.
8
A Case of Mirror-Image Crossed Thalamic Aphasia With Jargon Agraphia.一例伴有行语性失写的镜像交叉性丘脑性失语病例。
Cureus. 2024 May 19;16(5):e60637. doi: 10.7759/cureus.60637. eCollection 2024 May.
9
An inclusive multivariate approach to neural localization of language components.一种包容的多变量方法，用于语言成分的神经定位。
Brain Struct Funct. 2024 Jun;229(5):1243-1263. doi: 10.1007/s00429-024-02800-9. Epub 2024 May 2.
10
A modified neural circuit framework for semantic memory retrieval with implications for circuit modulation to treat verbal retrieval deficits.一种用于语义记忆检索的改良神经回路框架，对回路调制以治疗言语检索缺陷具有启示意义。
Brain Behav. 2024 May;14(5):e3490. doi: 10.1002/brb3.3490.
本文引用的文献
1
Potentiation of sensory responses in ventrobasal thalamus in vivo via selective modulation of mGlu1 receptors with a positive allosteric modulator.在体通过正向变构调节剂选择性调节 mGlu1 受体增强腹侧基底丘脑的感觉反应。
Neuropharmacology. 2012 Mar;62(4):1695-9. doi: 10.1016/j.neuropharm.2011.11.015. Epub 2011 Dec 7.
2
Motor response selection in overt sentence production: a functional MRI study.口语句子产生中的运动反应选择：一项 fMRI 研究。
Front Psychol. 2011 Sep 30;2:253. doi: 10.3389/fpsyg.2011.00253. eCollection 2011.
3
Dynamic-intentional thalamic aphasia: a failure of lexical-semantic self-activation.动态意向性丘脑失语症：词汇语义自我激活的失败。
Neurocase. 2011 Aug;17(4):313-7. doi: 10.1080/13554794.2010.504731.
4
Neural correlates of abstract verb processing.抽象动词加工的神经关联。
J Cogn Neurosci. 2011 Jan;23(1):106-18. doi: 10.1162/jocn.2010.21414.
5
The corticothalamocortical circuit drives higher-order cortex in the mouse.皮质丘脑皮质回路驱动小鼠的高级皮质。
Nat Neurosci. 2010 Jan;13(1):84-8. doi: 10.1038/nn.2449. Epub 2009 Dec 6.
6
Synchrony in the interconnected circuitry of the thalamus and cerebral cortex.丘脑与大脑皮层相互连接回路中的同步性。
Ann N Y Acad Sci. 2009 Mar;1157:10-23. doi: 10.1111/j.1749-6632.2009.04534.x.
7
Neural substrates of object identification: Functional magnetic resonance imaging evidence that category and visual attribute contribute to semantic knowledge.物体识别的神经基础：功能磁共振成像证据表明类别和视觉属性有助于语义知识。
J Int Neuropsychol Soc. 2009 Mar;15(2):169-81. doi: 10.1017/S1355617709090468.
8
The primate centromedian-parafascicular complex: anatomical organization with a note on neuromodulation.灵长类动物的中央中核-束旁复合体：解剖结构及神经调节相关注释
Brain Res Bull. 2009 Feb 16;78(2-3):122-30. doi: 10.1016/j.brainresbull.2008.09.016. Epub 2008 Oct 26.
9
Evidence for nonreciprocal organization of the mouse auditory thalamocortical-corticothalamic projection systems.小鼠听觉丘脑皮质-皮质丘脑投射系统非互惠组织的证据。
J Comp Neurol. 2008 Mar 10;507(2):1209-27. doi: 10.1002/cne.21602.
10
Supplementary motor area and presupplementary motor area: targets of basal ganglia and cerebellar output.辅助运动区和前辅助运动区：基底神经节和小脑输出的靶点。
J Neurosci. 2007 Oct 3;27(40):10659-73. doi: 10.1523/JNEUROSCI.3134-07.2007.
Zotero 插件