Song Juhyun
Department of Anatomy, Chonnam National University Medical School, Hwasun 58128, Korea.
Clin Nutr Res. 2022 Jul 25;11(3):159-170. doi: 10.7762/cnr.2022.11.3.159. eCollection 2022 Jul.
Ischemic stroke and Alzheimer's disease (AD) are representative geriatric diseases with a rapidly increasing prevalence worldwide. Recent studies have reported an association between ischemic stroke neuropathology and AD neuropathology. Ischemic stroke shares some similar characteristics with AD, such as glia activation-induced neuroinflammation, amyloid beta accumulation, and neuronal cell loss, as well as some common risk factors with AD progression. Although there are considerable similarities in neuropathology between ischemic stroke and AD, no studies have ever compared specific genetic changes of brain cortex between ischemic stroke and AD. Therefore, in this study, I compared the cerebral cortex transcriptome profile of 5xFAD mice, an AD mouse model, with those of middle cerebral artery occlusion (MCAO) mice, an ischemic stroke mouse model. The data showed that the expression of many genes with important functional implications in MCAO mouse brain cortex were related to synaptic dysfunction and neuronal cell death in 5xFAD mouse model. In addition, changes in various protein-coding RNAs involved in synaptic plasticity, amyloid beta accumulation, neurogenesis, neuronal differentiation, glial activation, inflammation and neurite outgrowth were observed. The findings could serve as an important basis for further studies to elucidate the pathophysiology of AD in patients with ischemic stroke.
缺血性中风和阿尔茨海默病（AD）是全球患病率迅速上升的代表性老年疾病。最近的研究报告了缺血性中风神经病理学与AD神经病理学之间的关联。缺血性中风与AD有一些相似的特征，如胶质细胞激活诱导的神经炎症、β淀粉样蛋白积累和神经元细胞丢失，以及与AD进展的一些共同风险因素。尽管缺血性中风和AD在神经病理学上有相当多的相似之处，但从未有研究比较过缺血性中风和AD之间大脑皮层的特定基因变化。因此，在本研究中，我将AD小鼠模型5xFAD小鼠的大脑皮层转录组谱与缺血性中风小鼠模型大脑中动脉闭塞（MCAO）小鼠的转录组谱进行了比较。数据显示，在MCAO小鼠大脑皮层中许多具有重要功能意义的基因表达与5xFAD小鼠模型中的突触功能障碍和神经元细胞死亡有关。此外，还观察到参与突触可塑性、β淀粉样蛋白积累、神经发生、神经元分化、胶质细胞激活、炎症和神经突生长的各种蛋白质编码RNA的变化。这些发现可为进一步研究阐明缺血性中风患者AD的病理生理学提供重要依据。
