Misra M, Thakur R, Bhandari K
Clin Cardiol. 1987 Jun;10(6):365-7. doi: 10.1002/clc.4960100613.
A case on concomitant atenolol-verapamil therapy for hypertension and angina pectoris, developing sinus arrest and life-threatening bradycardia is described. The complication occurred with low doses of both the agents and normal electrophysiologic status of the heart. The example suggests that pharmacodynamic synergism contributes more than pharmacokinetic interaction causing adverse reactions during beta blocker-verapamil therapy.
描述了一例使用阿替洛尔-维拉帕米联合治疗高血压和心绞痛时发生窦性停搏和危及生命的心动过缓的病例。该并发症在两种药物低剂量使用且心脏电生理状态正常的情况下发生。该病例表明，在β受体阻滞剂-维拉帕米治疗期间，药效学协同作用比药代动力学相互作用对不良反应的影响更大。
