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结缔组织病中的SL/Ki系统:发病率及临床关联

The SL/Ki system in connective tissue diseases: incidence and clinical associations.

作者信息

Riboldi P, Asero R, Origgi L, Crespi S

出版信息

Clin Exp Rheumatol. 1987 Jan-Mar;5(1):29-33.

PMID:3594962
Abstract

In a clinical and serological study carried out on 516 subjects with different connective tissue diseases, anti-SL/Ki autoantibodies were found in 12% of patients with systemic lupus erythematosus, 14% of patients with mixed connective tissue disease, 18% of patients with different kinds of vasculitides, and 3% of patients with Sjögren's syndrome. In SLE patients, no significant clinical association was found with the SL/Ki system, but the incidence of the antibody was nearly three-fold higher in males than in females. Most sera contained other autoantibodies; a statistically significant serological association has been found between SL/Ki and PCNA antibodies (p less than 0.05).

摘要

在一项针对516名患有不同结缔组织疾病的受试者开展的临床和血清学研究中,系统性红斑狼疮患者中有12%、混合性结缔组织病患者中有14%、各类血管炎患者中有18%以及干燥综合征患者中有3%检测出抗SL/Ki自身抗体。在系统性红斑狼疮患者中,未发现与SL/Ki系统存在显著临床关联,但该抗体在男性中的发病率几乎是女性的三倍。大多数血清还含有其他自身抗体;已发现SL/Ki与增殖细胞核抗原(PCNA)抗体之间存在统计学显著的血清学关联(p小于0.05)。

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Increased interferon-gamma (IFN-gamma) levels produced in vitro by alloactivated T lymphocytes in systemic sclerosis and Raynaud's phenomenon.系统性硬化症和雷诺现象中同种异体激活的T淋巴细胞在体外产生的γ干扰素(IFN-γ)水平升高。
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