Kenger Emre Batuhan, Guveli Hakan, Ergun Can, Kaya Eda, Yilmaz Yusuf
Department of Nutrition and Dietetics, Bahcesehir University Faculty of Health Sciences, Istanbul, Turkey.
Istanbul University-Cerrahpasa, Istanbul, Turkey.
Hepatol Forum. 2020 Jan 17;1(1):14-19. doi: 10.14744/hf.2020.0004. eCollection 2020 Jan.
Resting metabolic (RMR) rate was shown to be associated with chronic inflammatory conditions. In this study, we aimed to investigate whether RMR differs significantly in patients with non-alcoholic steatohepatitis (NASH) from patients with non-alcoholic fatty liver disease (NAFLD) without evidence of inflammation.
Forty-two biopsy-proven NASH were compared with 37 NAFLD patients, who had normal serum transaminases and no evidence of fibrosis based on transient elastography examination. In the interviews, patients' levels of physical activity and dietary habits were recorded, and bioimpedance analysis was performed. The RMRs were calculated using an indirect calorimeter.
RMR did not significantly differ between patients with NASH and NAFLD without steatohepatitis in both genders (p=0.695 in males, p=0.256 in females). However, only in female patients RMR rate per body weight was significantly higher in patients with NASH (22.3 [17.2-26.6] cal/kg to 20.2 [12.2-26.1] cal/kg, p=0.020).
In conclusion, RMR was not significantly associated with steatohepatitis in patients with NAFLD. Considering the minimizing the effects of body weight, RMR rate per body weight may be used over RMR in the evaluation of the inflammatory status of the NAFLD.
静息代谢（RMR）率已被证明与慢性炎症状态相关。在本研究中，我们旨在调查非酒精性脂肪性肝炎（NASH）患者的RMR与无炎症证据的非酒精性脂肪肝（NAFLD）患者相比是否存在显著差异。
将42例经活检证实的NASH患者与37例NAFLD患者进行比较，后者血清转氨酶正常，且基于瞬时弹性成像检查无纤维化证据。在访谈中，记录患者的身体活动水平和饮食习惯，并进行生物电阻抗分析。使用间接热量计计算RMR。
NASH患者与无脂肪性肝炎的NAFLD患者的RMR在男女两性中均无显著差异（男性p = 0.695，女性p = 0.256）。然而，仅在女性患者中，NASH患者的每体重RMR率显著更高（22.3 [17.2 - 26.6] 千卡/千克对20.2 [12.2 - 26.1] 千卡/千克，p = 0.020）。
总之，NAFLD患者的RMR与脂肪性肝炎无显著关联。考虑到尽量减少体重的影响，在评估NAFLD的炎症状态时，每体重RMR率可能比RMR更适用。
