Zhang Ke, He Chunmei, Deng Qiaoting, Li Wengen, Zhong Zhixiong, Hou Jingyuan
Department of Rheumatology, Meizhou People's Hospital (Huangtang Hospital), Meizhou Hospital Affiliated to Sun Yat-sen University, Meizhou, P. R. China.
Department of Research Experimental Center, Meizhou People's Hospital (Huangtang Hospital), Meizhou Hospital Affiliated to Sun Yat-sen University, Meizhou, P. R. China.
Arch Rheumatol. 2021 Oct 18;37(1):59-66. doi: 10.46497/ArchRheumatol.2022.8870. eCollection 2022 Mar.
This study aims to estimate predicted factors for maternal and fetal outcomes in Hakka pregnant women with systemic lupus erythematosus (SLE) in the southern China.
Between June 2014 and February 2020, we retrospectively analyzed the data of a total of 123 singleton pregnant women with SLE (mean age: 27.1±4.1 years; range, 19 to 39 years) who were referred to our rheumatology clinic. Demographic, clinical, and laboratory data of the patients were recorded. Adverse pregnancy outcomes (APOs) were assessed.
Multivariate logistic regression analysis revealed that preeclampsia was associated with the increased odds of APOs (odds ratios [OR]=9.538, 95% confidence interval [CI]: 2.055-44.271, p=0.004), premature birth (OR=14.289, 95% CI: 3.596-56.777, p<0.001) and low birth weight (OR=8.275, 95% CI: 2.117-32.345, p=0.002). Anti-double-stranded deoxyribonucleic acid (anti-dsDNA) antibody positivity was the predictor of APOs (OR=2.165, 95% CI: 1.034-4.532, p=0.040), premature birth (OR=2.849, 95% CI: 1.220-6.657, p=0.016) and pregnancy loss (OR=3.004, 95% CI: 1.086-8.305, p=0.034). The use of hydroxychloroquine and prednisone was associated with the decreased odds of APOs (OR=0.412, 95% CI: 0.198-0.860, p=0.018) and pregnancy loss (OR=0.304, 95% CI: 0.111-0.831, p=0.020).
Our study results indicate that preeclampsia, anti-dsDNA antibody positivity, and the use of hydroxychloroquine and prednisone are independent predictors of pregnancy outcomes.
本研究旨在评估中国南方客家系统性红斑狼疮（SLE）孕妇母婴结局的预测因素。
2014年6月至2020年2月期间，我们回顾性分析了转诊至我院风湿科门诊的123名单胎SLE孕妇（平均年龄：27.1±4.1岁；范围：19至39岁）的数据。记录患者的人口统计学、临床和实验室数据。评估不良妊娠结局（APO）。
多因素逻辑回归分析显示，子痫前期与APO几率增加相关（比值比[OR]=9.538，95%置信区间[CI]：2.055 - 44.271，p = 0.004）、早产（OR = 14.289，95% CI：3.596 - 56.777，p < 0.001）和低出生体重（OR = 8.275，95% CI：2.117 - 32.345，p = 0.002）。抗双链脱氧核糖核酸（抗dsDNA）抗体阳性是APO（OR = 2.165，95% CI：1.034 - 4.532，p = 0.040）、早产（OR = 2.849，95% CI：1.220 - 6.657，p = 0.016）和妊娠丢失（OR = 3.004，95% CI：1.086 - 8.305，p = 0.034）的预测因素。使用羟氯喹和泼尼松与APO几率降低（OR = 0.412，95% CI：0.198 - 0.860，p = 0.
