Rheumatology and Immunology Unit, Department of Clinical and Experimental Sciences, University of Brescia, ASST Spedali Civili, Brescia, Italy; I.M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University), Russia.
Rheumatology and Immunology Unit, Department of Clinical and Experimental Sciences, University of Brescia, ASST Spedali Civili, Brescia, Italy.
Best Pract Res Clin Endocrinol Metab. 2019 Dec;33(6):101322. doi: 10.1016/j.beem.2019.101322. Epub 2019 Sep 11.
Pregnancy in autoimmune diseases remains an argument of debate. In last years great improvements were done and with the correct medical support women with disease such as Systemic Lupus Erythematosus or Antiphospholipid Syndrome can afford a pregnancy and have healthy babies. The starting point is a good counselling. Women should be informed about risks that can occur taking some medications while pregnant and, on the other hand, that there are medications that can be safety assumed during pregnancy. Furthermore, there are known maternal risks factor such as the presence of antiphospholipid antibodies or anti-Ro/SSA antibodies that must be carefully manage by both rheumatologists and obstetrics. In addition, also disease activity during pregnancy can represent an issue. For all these reason, a multidisciplinary approach is mandatory in order to give our patients an optimal medical support, before, during and after pregnancy.
妊娠与自身免疫性疾病仍然存在争议。近年来，我们取得了重大进展，通过正确的医疗支持，患有系统性红斑狼疮或抗磷脂综合征等疾病的女性可以妊娠并生育健康的婴儿。良好的咨询是起点。应该告知女性在怀孕期间服用某些药物可能出现的风险，另一方面，也有一些药物在怀孕期间可以安全使用。此外，已知的母体风险因素，如抗磷脂抗体或抗 Ro/SSA 抗体的存在，需要由风湿病学家和产科医生共同仔细管理。此外，妊娠期间的疾病活动也可能是一个问题。由于所有这些原因，必须采用多学科方法，以便在妊娠前、妊娠期间和妊娠后为我们的患者提供最佳的医疗支持。
