Expressional Evaluation of C/EBP Family, SREBP1, and Steroid Hormone Receptors in the Epididiymal Fat of Postnatally Developing Mouse.

The differentiation and development of preadipocyte into mature adipocyte e regulated by transcription factors, such as CCAAT enhancer binding protein () gene family and sterol regulatory element binding transcription factor 1 (). Steroid hormones give influences on the development and function of adipocyte. The present resech examined expression patterns of CCAAT enhancer binding protein alpha (), CCAAT enhancer binding protein beta (), CCAAT enhancer binding protein gamma (), sterol regulatory element binding transcription factor 1 (), androgen receptor (), and estrogen receptors () among different epididymal fat pts during postnatal period by quantitative real-time polymerase chain reaction. In the distal epididymal fat, expression of , , , , , and 2 was increased until 12 months of age, while expression of was decreased at 5 months of age and was not detectable after 8 months of age. In the proximal epididymal fat, transcript levels of and were increased at 8 months of age, followed by decreases of and transcript levels at 12 months of age. An additional increase of expression was observed at 12 months of age. Expression of and 2 were increased until 8 months of age, followed by a drop of expression level at 12 months of age. Expression pattern of was simil to that in the distal epididymal fat. In the tail epididymal fat, expression of , , , , and 2 was increased with age. was not detectable at all. The highest level of was observed at 8 months of age. These data suggest the possibility of developmental and functional differentiation among the epididymal fat pts.