Neuroscience Research Center, Department of Epidemiology and Biostatistics, Qom University of Medical Sciences, Qom, Iran.
Department of Public Health, Faculty of Health, Qom University of Medical Sciences, Qom, Iran.
Ghana Med J. 2021 Sep;55(3):206-212. doi: 10.4314/gmj.v55i3.5.
Brucellosis is one of the major health problems in many areas of the world, especially in the Mediterranean and the Middle East regions.
To determine the epidemiological characteristics, clinical signs, and risk factors of relapse rate in patients with brucellosis, Qom Province, Iran.
A descriptive-analytic study was conducted on 410 confirmed brucellosis cases in Qom Province, central Iran, from 2015 to 2019, based on epidemiological checklists and according to the Iran Ministry of Health and Medical Education (MOHME). Univariate and multiple logistic regression analyses were conducted using Stata software version 14.
The relapse rate of brucellosis was 6.6% until nine months after starting the treatment, and all recurrent cases were infected by . Based on univariate logistic regression analysis, the delayed treatment and type species of were significant factors affecting the relapse of brucellosis. The relapse rates were 5.4%, 6.2%, and 20.0% in patients whose delayed treatments were <50, 51-150, and >151days, respectively. Based on the multiple logistic regression, it was observed that delayed treatment >50 days increased the rate of relapse more than four times.
The delayed initiation of treatment was a significant factor influencing the relapse of brucellosis; therefore, it is necessary to provide enough diagnostic and laboratory facilities, and people need to be educated about the signs and symptoms of the disease.
Funding for this research was provided by the Research and Technology Center of Qom University of Medical Sciences, Qom, Iran.
布鲁氏菌病是世界许多地区，特别是地中海和中东地区的主要健康问题之一。
确定伊朗库姆省布鲁氏菌病患者的流行病学特征、临床症状和复发率的危险因素。
本研究采用描述性分析方法，对 2015 年至 2019 年期间伊朗中部库姆省 410 例确诊布鲁氏菌病患者进行了研究，依据是流行病学检查表，并根据伊朗卫生部和医学教育部（MOHME）的标准进行。使用 Stata 软件版本 14 进行单变量和多变量逻辑回归分析。
在开始治疗后 9 个月内，布鲁氏菌病的复发率为 6.6%，所有复发病例均由 感染。基于单变量逻辑回归分析，延迟治疗和 种属是影响布鲁氏菌病复发的显著因素。治疗延迟<50、51-150 和>151 天的患者的复发率分别为 5.4%、6.2%和 20.0%。基于多变量逻辑回归，观察到治疗延迟>50 天使复发率增加了四倍以上。
延迟开始治疗是影响布鲁氏菌病复发的一个重要因素；因此，有必要提供足够的诊断和实验室设施，并对疾病的症状和体征进行教育。
本研究的资金由伊朗库姆医科大学研究与技术中心提供。
