Department of Pharmacy, Xinjiang Medical University Affiliated First Hospital, Ürümqi, 830011, China.
The Precision Medicine Center of Xinjiang Medical University, Ürümqi, 830011, China.
Mol Biol Rep. 2022 Oct;49(10):9535-9541. doi: 10.1007/s11033-022-07844-w. Epub 2022 Aug 11.
Hyperhomocysteinemia (HHcy) is a common complication in Chinese hypertensive patients and associated with methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism, folate, and vitamin B12 (Vit B12) status. This study evaluated the associations of MTHFR C677T polymorphism, folate, and Vit B12 with H-type hypertension.
887 eligible patients with essential hypertension were included. Patients were divided into two groups according to the Hcy level, the H-type hypertension group and the normal hypertension group. Related risk factors such as MTHFR polymorphism, folate and Vit B12 status were analyzed in the two groups. Age, gender, SBP, DBP, MTHFR C677T genotype, folate and Vit B12 differed significantly between H-type hypertension and normal hypertension groups (P < 0.05). MTHFR 677TT variant, gender, folate, and Vit B12 were independent risk factors for the occurrence of H-type hypertension. The risk for TT carriers was 8 times higher than that of CC and CT carriers [OR (95% CI) 8.248 (5.274-12.899)]. Male patients had almost fivefold higher odds than female patients [OR (95% CI) 4.923 (2.741-8.842)]. Folate level of patients with H-type hypertension decreased with the C to T substitution of MTFHR C677T gene (P < 0.05), while Vit B12 level was not associated with the gene (P > 0.05).
MTHFR 677TT variant, gender, folate, and Vit B12 were risk factors for the occurrence of H-type hypertension. Folate but not Vit B12 was associated with MTFHR C677T polymorphism in patients with H-type hypertension. Accordingly, the above factors may be considered in the prevention and treatment of hypertension.
高同型半胱氨酸血症（HHcy）是中国高血压患者的常见并发症，与亚甲基四氢叶酸还原酶（MTHFR）C677T 多态性、叶酸和维生素 B12（Vit B12）状态有关。本研究评估了 MTHFR C677T 多态性、叶酸和 Vit B12 与 H 型高血压的关系。
纳入了 887 例符合条件的原发性高血压患者。根据 Hcy 水平将患者分为 H 型高血压组和正常高血压组。分析两组相关危险因素，如 MTHFR 多态性、叶酸和 Vit B12 状态。H 型高血压组与正常高血压组在年龄、性别、SBP、DBP、MTHFR C677T 基因型、叶酸和 Vit B12 方面差异有统计学意义（P < 0.05）。MTHFR 677TT 变体、性别、叶酸和 Vit B12 是 H 型高血压发生的独立危险因素。TT 携带者的风险是 CC 和 CT 携带者的 8 倍[比值比（95%置信区间）8.248（5.274-12.899）]。男性患者的患病风险是女性患者的近 5 倍[比值比（95%置信区间）4.923（2.741-8.842）]。随着 MTFHR C677T 基因 C 到 T 取代，H 型高血压患者的叶酸水平降低（P < 0.05），而 Vit B12 水平与基因无关（P > 0.05）。
MTHFR 677TT 变体、性别、叶酸和 Vit B12 是 H 型高血压发生的危险因素。在 H 型高血压患者中，叶酸而不是 Vit B12 与 MTFHR C677T 多态性有关。因此，在高血压的预防和治疗中可以考虑上述因素。
