Neurobiology Laboratory, School of Life Sciences, Jawaharlal Nehru University, New Delhi, 110067, India.
Department of Biochemistry, Maharshi Dayanand University, Rohtak, 124001, Haryana, India.
Neuromolecular Med. 2023 Jun;25(2):163-178. doi: 10.1007/s12017-022-08724-z. Epub 2022 Aug 11.
Quercetin is a polyphenolic bioactive compound highly enriched in dietary fruits, vegetables, nuts, and berries. Quercetin and its derivatives like rutin and hyperoside are known for their beneficial effects in various neurological conditions including epilepsy. The clinical studies of quercetin and its derivatives in relation to epilepsy are limited. This review provides the evidence of most recent knowledge of anticonvulsant properties of quercetin and its derivatives on preclinical studies. Additionally, the studies demonstrating antiseizure potential of various plants extracts enriched with quercetin and its derivatives has been included in this review. Herein, we have also discussed neuroprotective effect of these bioactive compound and presented underlying mechanisms responsible for anticonvulsant properties in brief. Finally, limitations of quercetin and its derivatives as antiseizure compounds as well as possible strategies to enhance efficacy have also been discussed.
槲皮素是一种多酚类生物活性化合物，在膳食水果、蔬菜、坚果和浆果中含量很高。槲皮素及其衍生物如芦丁和圣草酚因在各种神经疾病中具有有益作用而闻名，包括癫痫。关于槲皮素及其衍生物与癫痫相关的临床研究有限。本综述提供了关于槲皮素及其衍生物在临床前研究中抗惊厥特性的最新知识证据。此外，还包括了各种富含槲皮素及其衍生物的植物提取物的抗惊厥潜力的研究。在此，我们还讨论了这些生物活性化合物的神经保护作用，并简要介绍了其抗惊厥特性的潜在机制。最后，还讨论了槲皮素及其衍生物作为抗惊厥化合物的局限性以及提高疗效的可能策略。
