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心脏瓣膜置换术后血栓形成的发生、诊断与治疗

Occurrence, diagnosis and treatment of thromboses of heart valve prostheses.

作者信息

Dominik J, Nicovský J, Semrád B, Suchánek M, Vespalec J

出版信息

Cor Vasa. 1987;29(2):109-15.

PMID:3595144
Abstract

In the period from 1978 to 1985, the authors implanted a total of 667 Björk-Shiley heart valve prostheses. In the same period, they performed 6 times reoperation for thrombosis of these valves. There was one reoperation for thrombosis per 271 years of life with a valve prosthesis, i.e. 0.36% per patient year. All 6 reoperations were successful and there was until now no recurrence of thrombosis in any of the reoperated patients. All cases involved were thrombosis of the flat disc Björk-Shiley valve. There was now no thrombosis of convexo-concave types, which the authors have been using since 1981. The most important preventive measure against the development of thrombosis is strict observance and control of anticoagulation regimen. Thrombosis of a disc valve prosthesis can in most cases be diagnosed on the basis of the clinical picture and X-ray evidence of restricted disc mobility. Diagnosis of thrombosis is an indication for urgent reoperation, which is preferred to an uncertain attempt at thrombolysis.

摘要

在1978年至1985年期间,作者共植入了667个 Björk-Shiley心脏瓣膜假体。在同一时期,他们对这些瓣膜的血栓形成进行了6次再次手术。每植入一个瓣膜假体,每271年就会有一次因血栓形成而进行的再次手术,即每年每位患者的发生率为0.36%。所有6次再次手术均获成功,且截至目前,接受再次手术的患者中无一例血栓形成复发。所有相关病例均为平盘型Björk-Shiley瓣膜的血栓形成。自1981年以来作者一直在使用的凸凹型瓣膜目前未出现血栓形成。预防血栓形成最重要的措施是严格遵守和控制抗凝方案。在大多数情况下,盘状瓣膜假体的血栓形成可根据临床表现和X线显示的瓣膜活动受限证据作出诊断。血栓形成的诊断是紧急再次手术的指征,这比不确定的溶栓尝试更可取。

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