Huo Da, Su Fang, Cui Wei, Liu Shilin, Zhang Libin, Yang Hongsheng, Sun Lina
CAS Key Laboratory of Marine Ecology and Environmental Sciences, Institute of Oceanology, Chinese Academy of Sciences, Qingdao 266071, China; Laboratory for Marine Ecology and Environmental Science, Qingdao National Laboratory for Marine Science and Technology, Qingdao 266237, China; University of Chinese Academy of Sciences, Beijing 100049, China; Shandong Province Key Laboratory of Experimental Marine Biology, Qingdao 266071, China.
CAS Key Laboratory of Marine Ecology and Environmental Sciences, Institute of Oceanology, Chinese Academy of Sciences, Qingdao 266071, China; Laboratory for Marine Ecology and Environmental Science, Qingdao National Laboratory for Marine Science and Technology, Qingdao 266237, China; University of Chinese Academy of Sciences, Beijing 100049, China; Shandong Province Key Laboratory of Experimental Marine Biology, Qingdao 266071, China.
Mar Pollut Bull. 2022 Sep;182:113993. doi: 10.1016/j.marpolbul.2022.113993. Epub 2022 Aug 8.
When encountering adverse environmental conditions, some holothurians can eject their internal organs in a process called evisceration. As global warming intensified, eviscerated and intact sea cucumbers both experience heat stress, but how they performed was uncertain. We constructed 24 metabolomics profiles to reveal the metabolite changes of eviscerated and intact sea cucumbers under normal and high temperature conditions, respectively. Carboxylic acids and fatty acyls were the most abundant metabolic categories in evisceration and heat stress treatments, respectively. Neural transduction was involved in sea cucumber evisceration and stress response, and the commonly enriched pathway was "neuroactive ligand-receptor interaction". Lipid metabolism in eviscerated sea cucumbers differed from those of intact individuals and was more seriously affected by heat stress. Choline is a key metabolite for revealing the evisceration mechanism. Our results contribute to understanding the mechanisms of evisceration in sea cucumbers, and how sea cucumbers might respond to increasingly warming ocean conditions.
当遇到不利的环境条件时，一些海参能够通过一种叫做排脏的过程排出它们的内脏。随着全球变暖加剧，排脏后的海参和完整的海参都会经历热应激，但它们的表现如何尚不确定。我们构建了24个代谢组学图谱，分别揭示排脏后的海参和完整海参在正常温度和高温条件下的代谢物变化。羧酸和脂肪酰基分别是排脏和热应激处理中最丰富的代谢类别。神经传导参与了海参的排脏和应激反应，共同富集的通路是“神经活性配体-受体相互作用”。排脏海参的脂质代谢与完整个体不同，且受热应激的影响更严重。胆碱是揭示排脏机制的关键代谢物。我们的研究结果有助于理解海参的排脏机制，以及海参如何应对海洋环境日益变暖的情况。
