中国南方传染性法氏囊病病毒的特性与致病性。
Characterization and pathogenicity of infectious bursal disease virus in Southern China.
机构信息
College of Animal Science, South China Agricultural University, Guangzhou 510642, P R China.
College of Animal Science, South China Agricultural University, Guangzhou 510642, P R China; Guangdong Provincial Animal Virus Vector Vaccine Engineering Technology Research Center, South China Agricultural University, Guangzhou 510642, P R China.
出版信息
Poult Sci. 2022 Oct;101(10):102018. doi: 10.1016/j.psj.2022.102018. Epub 2022 Jun 20.
Infectious bursal disease virus (IBDV) is a widespread pathogen that induces immunosuppression in 3 to 6-wk-old chickens, casuing great threaten to the poultry industry worldwide. Previously, the very virulent IBDV (vvIBDV) was mainly prevalent in China. In recent years, the novel variant IBDV (nvIBDV) occurred in China. In this study, we isolated 30 IBDV strains of IBDV from vaccinated chicken flocks in 8 provinces of southern China. Among these isolates, vvIBDV group (13/30) and nvIBDV group (17/30) were identified according to the genome sequencing and phylogenic analysis. Moreover, HB2021-5 and GD2021-17 have pathologic characteristics with severe bursal lesions, as evidenced by necrosis, depletion of lymphocytes, and follicle atrophy. Our findings provide an important reference for understanding the epidemiological status and the evolution of IBDV.
传染性囊病病毒（IBDV）是一种广泛存在的病原体，可导致 3 至 6 周龄的鸡产生免疫抑制，对全球家禽业造成巨大威胁。以前，非常强毒力的 IBDV（vvIBDV）主要在中国流行。近年来，新型变异 IBDV（nvIBDV）在中国出现。在本研究中，我们从中国南方 8 个省份接种疫苗的鸡群中分离出 30 株 IBDV。在这些分离株中，根据基因组测序和系统发育分析，鉴定出 vvIBDV 组（13/30）和 nvIBDV 组（17/30）。此外，HB2021-5 和 GD2021-17 具有严重的法氏囊病变的病理特征，表现为坏死、淋巴细胞耗竭和滤泡萎缩。我们的研究结果为了解 IBDV 的流行状况和进化提供了重要参考。
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