Walgenbach S, Junginger T, Rothmund M, Nagel K
Chirurg. 1987 Apr;58(4):248-51.
Squamous cell carcinoma of the anorectal junction originated from anal fistulas in two female patients with Crohn's disease which have been suffering from anal and rectovaginal fistulas for many years. In addition one tumour showed paraneoplastic parathyroid hormone synthesis. This findings point out Crohn's disease as a premalignant lesion. Chronic fistulas associated with Crohn's disease must be followed up carefully by clinical examination, endoscopy and biopsy. To prevent malignancy and to cure the anal region and the origin of such fistulas, resective surgical technics should be taken into consideration early.
两例患有克罗恩病的女性患者，其肛管直肠交界部鳞状细胞癌起源于肛瘘，她们多年来一直患有肛瘘和直肠阴道瘘。此外，其中一个肿瘤显示有副肿瘤性甲状旁腺激素合成。这些发现指出克罗恩病是一种癌前病变。与克罗恩病相关的慢性瘘管必须通过临床检查、内镜检查和活检进行仔细随访。为预防恶性肿瘤并治愈肛门区域以及此类瘘管的起源，应尽早考虑采用切除性手术技术。
