Department of Medical & Biological Engineering, Kyungpook National University, Daegu, Republic of Korea; Department of Neurosurgery, Kyungpook National University Hospital, Daegu, Republic of Korea.
Department of Medical & Biological Engineering, Kyungpook National University, Daegu, Republic of Korea; Division of Applied RI, Korea Institute of Radiological & Medical Sciences (KIRAMS), Seoul, Republic of Korea.
World Neurosurg. 2022 Oct;166:220-224. doi: 10.1016/j.wneu.2022.08.007. Epub 2022 Aug 8.
In gamma knife radiosurgery, the tumor response to radiation is an important predictor of clinical treatment results. Since brain tumors have different characteristics and growth patterns, depending on the type, the tumors' response to radiation are also different. Compared with various other clinical treatments, there is a dearth of research on the development of gamma knife-magnetic resonance imaging (MRI) preclinical experimental equipment. Hence, the identification of preclinical equipment necessity for experimental animals will provide meaningful data for the provision of clinical assistance to humans.
A device for stereotactic radiosurgery capable of MRI in small animals was developed. The feasibility of creating a preplan by means of small animal images was then assessed.
A device for stereotaxic surgery of small animals using a 48-channel MRI coil was developed using a 3 dimensional printer. Rat brain-MRI images were obtained with a 3.0 T MRI scanner using a multi-channel coil. The acquired MRI images were transferred to a GammaPlan workstation to establish a preplan.
To gamma rays to the targeted site on animals, a positioning device combined with a G-frame was mounted on a gamma knife. Planning of radiosurgery based on MRI images became possible with GammaPlan workstations.
Preclinical experiments using small animals are possible with the use of stereotactic devices. In clinical treatment, preclinical experimental results will provide meaningful information.
在伽玛刀放射外科中，肿瘤对辐射的反应是临床治疗结果的重要预测指标。由于脑肿瘤具有不同的特性和生长模式，因此肿瘤对辐射的反应也不同。与各种其他临床治疗方法相比，针对伽玛刀磁共振成像（MRI）临床前实验设备的研究还很少。因此，确定实验动物临床前设备的必要性将为向人类提供临床帮助提供有意义的数据。
开发一种可用于小动物 MRI 的立体定向放射外科设备。然后评估通过小动物图像创建预计划的可行性。
使用 3D 打印机开发了一种使用 48 通道 MRI 线圈的小动物立体定向手术设备。使用多通道线圈在 3.0T MRI 扫描仪上获得大鼠脑-MRI 图像。将获得的 MRI 图像传输到 GammaPlan 工作站以建立预计划。
为了将伽马射线引导至动物的靶向部位，将一个与 G 架结合的定位装置安装在伽玛刀上。借助 GammaPlan 工作站，可以根据 MRI 图像制定放射外科计划。
使用立体定向设备可以进行小动物临床前实验。在临床治疗中，临床前实验结果将提供有意义的信息。
