Kamiryo T, Berr S S, Lee K S, Kassell N F, Steiner L
Department of Neurological Surgery, Virginia Neurological Institute, Charlottesville, USA.
Acta Neurochir (Wien). 1995;133(1-2):87-92. doi: 10.1007/BF01404955.
A stereotactic device (SDM) was developed for performing consistent magnetic resonance imaging (MRI) of the rat brain. The SDM was developed by adapting a radiofrequency transmit/receive head coil of 4.4 cm inner diameter (quadrature birdcage head coil), and utilizing partial acrylic construction for the positioning elements. The small head coil provides improved resolution and accuracy of the image, while the stereotactic holder permits repeatable and accurate imaging of identified brain structures. This system provides several advantages over existing experimental MRI devices. The SDM ensures that the head is always placed in the center of the coil in a uniform fashion. Standardized positioning of the skull optimizes image quality and provides a consistent orientation of the brain. In addition, a widely-utilized coordinate system described by Paxinos and Watson can be employed to assist in the identification of structures and to facilitate surgical planning. The SDM is compatible with a recently-developed stereotactic device for radiosurgery with the Gamma Knife, thus permitting the planning and performance of experimental radiosurgery using the same coordinate system. The SDM also provides the ability to perform MRI and radiosurgery at different times, thus avoiding the need for prolonged anesthesia during an experimental study. Finally, the SDM allows repeated MRI of the same, identifiable positions in the brain during longitudinal experimental studies. The utility of this device is demonstrated here by examining the time course of cerebral damage that evolved within a radiosurgical focus after gamma irradiation.
开发了一种立体定向装置（SDM），用于对大鼠大脑进行一致的磁共振成像（MRI）。该SDM是通过改造内径为4.4厘米的射频发射/接收头部线圈（正交鸟笼式头部线圈），并利用部分丙烯酸结构制作定位元件而开发的。小型头部线圈可提高图像的分辨率和准确性，而立体定向支架则可对已识别的脑结构进行可重复且准确的成像。该系统相对于现有的实验性MRI设备具有多个优势。SDM可确保头部始终以均匀的方式放置在线圈中心。颅骨的标准化定位可优化图像质量，并为大脑提供一致的定向。此外，可采用由帕西诺斯和沃森描述的广泛使用的坐标系来辅助结构识别并便于手术规划。SDM与最近开发的用于伽玛刀放射外科手术的立体定向装置兼容，从而允许使用相同的坐标系进行实验性放射外科手术的规划和操作。SDM还具备在不同时间进行MRI和放射外科手术的能力，从而避免在实验研究期间需要长时间麻醉。最后，在纵向实验研究期间，SDM允许对大脑中相同的、可识别的位置进行重复MRI检查。通过检查伽玛射线照射后放射外科手术靶点内脑损伤的时间进程，证明了该装置的实用性。
