Department of Surgery, Extracorporeal Life Support Laboratory, Michigan Medicine, B560 MSRB II/SPC 5686, 1150 W. Medical Center Drive, Ann Arbor, MI 48109, USA.
Department of Surgery, Extracorporeal Life Support Laboratory, Michigan Medicine, B560 MSRB II/SPC 5686, 1150 W. Medical Center Drive, Ann Arbor, MI 48109, USA.
J Pediatr Surg. 2022 Nov;57(11):614-623. doi: 10.1016/j.jpedsurg.2022.07.006. Epub 2022 Jul 13.
For children with end-stage lung disease that cannot wean from extracorporeal life support (ECLS), a wearable artificial lung would permit extubation and provide a bridge to recovery or transplantation. We evaluate the function of the novel Pediatric MLung-a low-resistance, pumpless artificial lung developed specifically for children-in healthy animal subjects.
Adolescent "mini sheep" weighing 12-20 kg underwent left thoracotomy, cannulation of the main pulmonary artery (PA; inflow) and left atrium (outflow), and connection to the MLung.
Thirteen sheep were studied; 6 were supported for 7 days. Mean PA pressure was 23.9 ± 6.9 mmHg. MLung blood flow was 633±258 mL/min or 30.0 ± 16.0% of CO. MLung pressure drop was 4.4 ± 3.4 mmHg. Resistance was 7.2 ± 5.2 mmHg/L/min. Device outlet oxygen saturation was 99.0 ± 3.3% with inlet saturation 53.8 ± 7.3%. Oxygen delivery was 41.1 ± 18.4 mL O/min (maximum 84.9 mL/min) or 2.8 ± 1.5 mL O/min/kg. Platelet count significantly decreased; no platelet transfusions were required. Plasma free hemoglobin significantly increased only on day 7, at which point 2 of the animals had plasma free hemoglobin levels above 50 mg/dL.
The MLung provides adequate gas exchange at appropriate blood flows for the pediatric population in a PA-to-LA configuration. Further work remains to improve the biocompatibility of the device.
N/A.
对于无法从体外生命支持（ECLS）脱机的终末期肺病儿童，如果有一种可穿戴人工肺，可允许拔管并为恢复或移植提供桥梁。我们评估了专为儿童设计的新型儿科 MLung-低阻力、无泵人工肺在健康动物模型中的功能。
体重 12-20kg 的青少年“迷你羊”接受左开胸术，主肺动脉（PA；流入）和左心房（流出）插管，并与 MLung 相连。
研究了 13 只绵羊，其中 6 只支持 7 天。平均 PA 压为 23.9±6.9mmHg。MLung 血流为 633±258mL/min 或 CO 的 30.0±16.0%。MLung 压降为 4.4±3.4mmHg。阻力为 7.2±5.2mmHg/L/min。装置出口氧饱和度为 99.0±3.3%，入口饱和度为 53.8±7.3%。氧输送为 41.1±18.4mL O/min（最大 84.9mL/min）或 2.8±1.5mL O/min/kg。血小板计数明显下降；不需要血小板输注。仅在第 7 天，血浆游离血红蛋白显著增加，此时 2 只动物的血浆游离血红蛋白水平超过 50mg/dL。
在 PA 至 LA 构型中，MLung 为儿科人群提供了足够的气体交换和适当的血流。进一步的工作仍然需要改善设备的生物相容性。
无。
