Johnson and Johnson Vision Care Inc., 7500 Centurion Parkway, Jacksonville, FL 32256, Unites States.
J Optom. 2023 Apr-Jun;16(2):135-142. doi: 10.1016/j.optom.2022.06.004. Epub 2022 Aug 9.
Evaluate the performance of a photochromic contact lens in various lighting conditions throughout the day, including those indoor and outdoor environments where the photochromic contact lens is in a less active or inactive state.
Data from two clinical trials of a photochromic contact lens were analyzed to evaluate its performance in various light environments. Both studies involved a photochromic test lens (ACUVUE® OASYS with Transitions™ Light Intelligent Technology™) and a similar non-photochromic control lens (ACUVUE® OASYS 2-week with HYDRACLEAR® PLUS). The studies were both multi-visit, multi-site, 2-treatment by 3-period randomized crossover (i.e., Test/Control/Control or Control/Test/Test) dispensing studies, with follow-up visits after each 2-week dispensing period.
A total of 250 subjects were dispensed lenses across both studies, of which 237 total subjects completed. In situations where exposure to an activating light source is common (e.g., outdoors), the Test lens was preferred nearly 6:1 over the control lens. In situations where exposure to an activating light source is less common - indoors, driving at night, using digital devices -, the Test lens was still preferred over the control lens by margins of 4:1, nearly 4:1, and over 3:1 respectively. The Test lens was superior with respect to quality of vision, ability to see comfortably, clarity of vision, reduction of squinting while using computers and reduction of bright light while driving at night.
The photochromic test contact lens was rated superior to a non-photochromic control lens in environmental situations where the lens is in a less active or inactive state.
评估变色隐形眼镜在一天中各种光照条件下的性能，包括室内和室外环境，其中变色隐形眼镜处于不活跃或非活跃状态。
分析了一项变色隐形眼镜的两项临床试验数据，以评估其在各种光照环境下的性能。两项研究均涉及一款变色测试镜片（ACUVUE® OASYS with Transitions™ Light Intelligent Technology™）和一款类似的非变色对照镜片（ACUVUE® OASYS 2-week with HYDRACLEAR® PLUS）。这两项研究均为多访视、多地点、2 治疗 3 周期随机交叉（即测试/对照/对照或对照/测试/测试）分配研究，在每 2 周分配期后进行随访。
两项研究共分配了 250 名受试者镜片，其中 237 名受试者完成了全部研究。在暴露于激活光源的情况很常见的情况下（例如，室外），测试镜片的选择率几乎是对照镜片的 6 倍。在暴露于激活光源不太常见的情况下（例如，室内、夜间驾驶、使用数字设备），测试镜片的选择率仍然分别比对照镜片高出 4 倍、近 4 倍和 3 倍以上。测试镜片在视觉质量、舒适的视觉能力、视觉清晰度、使用计算机时减少眯眼以及夜间驾驶时减少强光方面均优于对照镜片。
在隐形眼镜处于不活跃或非活跃状态的环境情况下，变色测试隐形眼镜的评价优于非变色对照隐形眼镜。
