Mester Ulrich, Holz Frank, Kohnen Thomas, Lohmann Chris, Tetz Manfred
Department of Ophthalmology, Bundesknappschaft's Hospital, An der Klinik 10, Sulzbach, Germany.
J Cataract Refract Surg. 2008 Apr;34(4):608-15. doi: 10.1016/j.jcrs.2007.11.049.
To evaluate the effect of the AF-1 (UY) blue-light-filtering intraocular lens (IOL) with a yellow chromophore (Hoya) on visual function, including contrast vision and color perception.
Five clinical ophthalmology centers in Germany.
Two types of IOLs that were identical except for a blue-light filter on 1 were compared in a prospective randomized multicenter study with intraindividual comparisons. Postoperatively, uncorrected and best corrected visual acuities, pupil size, contrast vision (Early Treatment Diabetic Retinopathy Study chart, functional acuity contrast test, photopic, mesopic, mesopic with glare), and color discrimination (Farnsworth-Munsell 100-hue test, photopic and mesopic) were evaluated.
There were no significant differences between the 2 IOLs except in color vision dependent on blue light. Color perception for blue with the blue-light-filtering IOL was significantly reduced under mesopic conditions over the 12-month follow-up and under photopic conditions over 6 months. Despite the difference, all measured total error scores were within normal range and no patient reported impaired color vision.
The blue-light-filtering IOL with a yellow chromophore had no effect on contrast vision and visual acuity. However, the impairment of color perception for blue was statistically significant. The impairment of the blue perception did not exceed the normal range or induce subjective disturbance of color vision.
评估带有黄色发色团（Hoya）的AF-1（UY）蓝光滤过型人工晶状体（IOL）对视觉功能的影响，包括对比敏感度视力和色觉。
德国的五个临床眼科中心。
在一项前瞻性随机多中心研究中，对两种除一种带有蓝光滤过功能外其他均相同的人工晶状体进行个体内比较。术后评估未矫正和最佳矫正视力、瞳孔大小、对比敏感度视力（糖尿病视网膜病变早期治疗研究图表、功能性视力对比测试、明视觉、中间视觉、有眩光的中间视觉）以及颜色辨别能力（Farnsworth-Munsell 100色调测试，明视觉和中间视觉）。
除了依赖蓝光的色觉外，两种人工晶状体之间没有显著差异。在12个月的随访期间，中间视觉条件下以及6个月以上的明视觉条件下，使用蓝光滤过型人工晶状体时对蓝色的色觉明显降低。尽管存在差异，但所有测量的总误差分数均在正常范围内，且没有患者报告色觉受损。
带有黄色发色团的蓝光滤过型人工晶状体对对比敏感度视力和视力没有影响。然而，对蓝色的色觉损害具有统计学意义。蓝色觉的损害未超过正常范围或引起色觉的主观干扰。
