Nutrition and Obesities: Systemic Approaches Research Group (Nutri-Omics), Sorbonne Université, INSERM, F-75013 Paris, France.
Labex Inflamex, Université Sorbonne Paris Nord, INSERM, F-93000 Bobigny, France.
Cells. 2022 Jul 27;11(15):2310. doi: 10.3390/cells11152310.
The expansion of adipose tissue is an adaptive mechanism that increases nutrient buffering capacity in response to an overall positive energy balance. Over the course of expansion, the adipose microenvironment undergoes continual remodeling to maintain its structural and functional integrity. However, in the long run, adipose tissue remodeling, typically characterized by adipocyte hypertrophy, immune cells infiltration, fibrosis and changes in vascular architecture, generates mechanical stress on adipose cells. This mechanical stimulus is then transduced into a biochemical signal that alters adipose function through mechanotransduction. In this review, we describe the physical changes occurring during adipose tissue remodeling, and how they regulate adipose cell physiology and promote obesity-associated dysfunction in adipose tissue.
脂肪组织的扩张是一种适应性机制，可增加营养缓冲能力，以应对整体正能 量平衡。在扩张过程中，脂肪微环境不断进行重塑，以维持其结构和功能的完整性。 然而，从长远来看，脂肪组织重塑通常以脂肪细胞肥大、免疫细胞浸润、纤维化和血 管结构变化为特征，会对脂肪细胞产生机械应力。这种机械刺激随后通过机械转导 转化为改变脂肪细胞功能的生化信号。在这篇综述中，我们描述了脂肪组织重塑过 程中发生的物理变化，以及它们如何调节脂肪细胞生理学并促进脂肪组织与肥胖相 关的功能障碍。
